TY - JOUR
T1 - Substitutes and colloidal system for vitreous replacement and drug delivery
T2 - Recent progress and future prospective
AU - Thacker, Minal
AU - Tseng, Ching Li
AU - Lin, Feng Huei
N1 - Funding Information:
Funding: We thank for the funding support from National Health Research Institute, Taiwan, with the grant no. 09A1-BNGP01-043 and integrated research grant in health and medical sciences at no. of NHRI-EX109-10933SI.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/1
Y1 - 2021/1
N2 - Vitreoretinal surgeries for ocular diseases such as complicated retinal detachment, diabetic retinopathy, macular holes and ocular trauma has led to the development of various tamponades over the years in search for an ideal vitreous substitute. Current clinically used tamponade agents such as air, perfluorocarbons, silicone oil and expansile gases serve only as a short-term solution and harbors various disadvantages. However, an ideal long-term substitute is yet to be discovered and recent research emphasizes on the potential of polymeric hydrogels as an ideal vitreous substitute. This review highlights the recent progress in the field of vitreous substitution. Suitability and adverse effects of various tamponade agents in present day clinical use and biomaterials in the experimental phase have been outlined and discussed. In addition, we introduced the anatomy and functions of the native vitreous body and the pathological conditions which require vitreous replacement.
AB - Vitreoretinal surgeries for ocular diseases such as complicated retinal detachment, diabetic retinopathy, macular holes and ocular trauma has led to the development of various tamponades over the years in search for an ideal vitreous substitute. Current clinically used tamponade agents such as air, perfluorocarbons, silicone oil and expansile gases serve only as a short-term solution and harbors various disadvantages. However, an ideal long-term substitute is yet to be discovered and recent research emphasizes on the potential of polymeric hydrogels as an ideal vitreous substitute. This review highlights the recent progress in the field of vitreous substitution. Suitability and adverse effects of various tamponade agents in present day clinical use and biomaterials in the experimental phase have been outlined and discussed. In addition, we introduced the anatomy and functions of the native vitreous body and the pathological conditions which require vitreous replacement.
KW - Biopolymer
KW - Vitreous substitute
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U2 - 10.3390/polym13010121
DO - 10.3390/polym13010121
M3 - Review article
AN - SCOPUS:85098863675
SN - 2073-4360
VL - 13
SP - 1
EP - 15
JO - Polymers
JF - Polymers
IS - 1
M1 - 121
ER -
