Substituent Effect on the Chlorination of 2-Alkoxypyridines to give 2-Chloropyridines under Vilsmeier-Haack Conditions

Long Li Lai; Pen Yuan Lin; Jy Shih Wang; Jih Ru Hwu; Min Jen Shiao; Shwu Chen Tsay

Substituent Effect on the Chlorination of 2-Alkoxypyridines to give 2-Chloropyridines under Vilsmeier-Haack Conditions

Long Li Lai, Pen Yuan Lin, Jy Shih Wang, Jih Ru Hwu, Min Jen Shiao, Shwu Chen Tsay

Research output: Contribution to journal › Article › peer-review

Abstract

Various substituted 2-alkoxypyridines were converted into the corresponding 2-chloropyridines in 28-91% yields by use of POCl₃ and DMF, in which the methyl, halogen, ester and nitro groups displayed an activating effect; in contrast, an amino group exhibited a deactivating effect.

Original language	English
Pages (from-to)	194-195
Number of pages	2
Journal	Journal of Chemical Research - Part S
Issue number	4
Publication status	Published - Apr 1996
Externally published	Yes

ASJC Scopus subject areas

General Chemistry

Cite this

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title = "Substituent Effect on the Chlorination of 2-Alkoxypyridines to give 2-Chloropyridines under Vilsmeier-Haack Conditions",

abstract = "Various substituted 2-alkoxypyridines were converted into the corresponding 2-chloropyridines in 28-91% yields by use of POCl3 and DMF, in which the methyl, halogen, ester and nitro groups displayed an activating effect; in contrast, an amino group exhibited a deactivating effect.",

author = "Lai, {Long Li} and Lin, {Pen Yuan} and Wang, {Jy Shih} and Hwu, {Jih Ru} and Shiao, {Min Jen} and Tsay, {Shwu Chen}",

year = "1996",

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language = "English",

pages = "194--195",

journal = "Journal of Chemical Research - Part S",

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T1 - Substituent Effect on the Chlorination of 2-Alkoxypyridines to give 2-Chloropyridines under Vilsmeier-Haack Conditions

AU - Lai, Long Li

AU - Lin, Pen Yuan

AU - Wang, Jy Shih

AU - Hwu, Jih Ru

AU - Shiao, Min Jen

AU - Tsay, Shwu Chen

PY - 1996/4

Y1 - 1996/4

N2 - Various substituted 2-alkoxypyridines were converted into the corresponding 2-chloropyridines in 28-91% yields by use of POCl3 and DMF, in which the methyl, halogen, ester and nitro groups displayed an activating effect; in contrast, an amino group exhibited a deactivating effect.

AB - Various substituted 2-alkoxypyridines were converted into the corresponding 2-chloropyridines in 28-91% yields by use of POCl3 and DMF, in which the methyl, halogen, ester and nitro groups displayed an activating effect; in contrast, an amino group exhibited a deactivating effect.

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ER -

Substituent Effect on the Chlorination of 2-Alkoxypyridines to give 2-Chloropyridines under Vilsmeier-Haack Conditions

Abstract

ASJC Scopus subject areas

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