Abstract
We systematically investigated the effects of five Chinese herbal drugs (Atractylodes macrocephala Koidz, Paeonia lactiflora Pall., Citrus aurantium L., Alpinia officinarum Hance and Magnolia officinalis Rehd. et Wils.) available in Taiwan on experimental gastric ulcers. Crude water extracts were tested against five experimental acute ulcers (stress ulcers, Shay's ulcers, aspirin- induced gastric ulcers, mepirizole- induced duodenal lesions and cysteamine- induced duodenal lesions) and two experimental chronic ulcers (acetic acid- induced and thermocautery ulcers). Atractylodes macrocephala possessed significant protective effects against acute and chronic experimental ulcers in male Wistar rats. Alpinia officinarum and the other extracts also displayed statistically significant activities. These Chinese herbal drugs therefore possess antisecretory and anti-ulcer activities.
| Original language | English |
|---|---|
| Pages (from-to) | 55-66 |
| Number of pages | 12 |
| Journal | Chinese Pharmaceutical Journal |
| Volume | 50 |
| Issue number | 1 |
| Publication status | Published - Feb 1998 |
Keywords
- Antiulcer agent
- Experimental gastric ulcers
- Ulcer protective effects
ASJC Scopus subject areas
- Bioengineering
- Pharmaceutical Science