TY - JOUR
T1 - Structure of a potential intermediate in cholesterol biosynthesis
AU - Spike, Thomas E.
AU - Wang, Andrew H.J.
AU - Paul, Ian C.
AU - Schroepfer, George J.
N1 - Funding Information:
These atoms were assigned isotropic temperature factors and the occupancy of the three sites was varied to give final values of 0.74(4), 0.61(5),and 0.66(6). J.C.S. CHEM.COMM.,1974 bility exists that not all hydroxylation reactions procede 14a-methylcholest-7-ene-3P,15P-diol in cholesterol bio-with retention of configuration. This latter possibility has synthesis. been suggested by other studies6 of the biosynthesis of non- This work was supported by grants from the National steroidal natural products in plants. Institutes of Health and the Illinois Heart Association. Additional information is clearly required to satisfy criteria4 for the assignment of an intermediary role of (Received, 25th February 1974; Com.
PY - 1974
Y1 - 1974
N2 - The structure of the epimer (at C-15) of 14α-methylcholest-7-ene- 3β,15-diol which is convertible into cholesterol upon incubation with rat liver homogenate preparations has been established as 14α-methyl-cholest- 7-ene-3β,15β-diol.
AB - The structure of the epimer (at C-15) of 14α-methylcholest-7-ene- 3β,15-diol which is convertible into cholesterol upon incubation with rat liver homogenate preparations has been established as 14α-methyl-cholest- 7-ene-3β,15β-diol.
UR - http://www.scopus.com/inward/record.url?scp=0010628629&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0010628629&partnerID=8YFLogxK
U2 - 10.1039/C39740000477
DO - 10.1039/C39740000477
M3 - Article
AN - SCOPUS:0010628629
SN - 0022-4936
SP - 477
EP - 478
JO - Journal of the Chemical Society, Chemical Communications
JF - Journal of the Chemical Society, Chemical Communications
IS - 12
ER -