Structure activity of topoisomerase i poisons related to hoechst 33342

Qun Sun; Barbra Gatto; Chiang Yu; Angela Liu; Leory F. Liu; Edmond J. LaVoie

doi:10.1016/S0960-894X(01)80831-3

Structure activity of topoisomerase i poisons related to hoechst 33342

Qun Sun, Barbra Gatto, Chiang Yu, Angela Liu, Leory F. Liu, Edmond J. LaVoie

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

A series of bisbenzimidazoles related to Hoechst 33342 were synthesized. Data on the relative activity of these bisbenzimidazoles as topoisomerase I poisons suggest that considerable flexibility exists in the location of the tertiary alkylamine moeity. With the exception of arylamine analogs, cytotoxicity was generally consistent with their relative potency as topoisomerase I poisons.

Original language	English
Pages (from-to)	2871-2876
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	24
DOIs	https://doi.org/10.1016/S0960-894X(01)80831-3
Publication status	Published - Dec 22 1994
Externally published	Yes

ASJC Scopus subject areas

Drug Discovery
Molecular Medicine
Molecular Biology
Biochemistry
Clinical Biochemistry
Pharmaceutical Science
Organic Chemistry

Access to Document

10.1016/S0960-894X(01)80831-3

Cite this

@article{9ee191bd2f48450d9fd39fe64c1039f7,

title = "Structure activity of topoisomerase i poisons related to hoechst 33342",

abstract = "A series of bisbenzimidazoles related to Hoechst 33342 were synthesized. Data on the relative activity of these bisbenzimidazoles as topoisomerase I poisons suggest that considerable flexibility exists in the location of the tertiary alkylamine moeity. With the exception of arylamine analogs, cytotoxicity was generally consistent with their relative potency as topoisomerase I poisons.",

author = "Qun Sun and Barbra Gatto and Chiang Yu and Angela Liu and Liu, {Leory F.} and LaVoie, {Edmond J.}",

year = "1994",

month = dec,

day = "22",

doi = "10.1016/S0960-894X(01)80831-3",

language = "English",

volume = "4",

pages = "2871--2876",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "24",

}

TY - JOUR

T1 - Structure activity of topoisomerase i poisons related to hoechst 33342

AU - Sun, Qun

AU - Gatto, Barbra

AU - Yu, Chiang

AU - Liu, Angela

AU - Liu, Leory F.

AU - LaVoie, Edmond J.

PY - 1994/12/22

Y1 - 1994/12/22

N2 - A series of bisbenzimidazoles related to Hoechst 33342 were synthesized. Data on the relative activity of these bisbenzimidazoles as topoisomerase I poisons suggest that considerable flexibility exists in the location of the tertiary alkylamine moeity. With the exception of arylamine analogs, cytotoxicity was generally consistent with their relative potency as topoisomerase I poisons.

AB - A series of bisbenzimidazoles related to Hoechst 33342 were synthesized. Data on the relative activity of these bisbenzimidazoles as topoisomerase I poisons suggest that considerable flexibility exists in the location of the tertiary alkylamine moeity. With the exception of arylamine analogs, cytotoxicity was generally consistent with their relative potency as topoisomerase I poisons.

UR - http://www.scopus.com/inward/record.url?scp=0028580735&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028580735&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(01)80831-3

DO - 10.1016/S0960-894X(01)80831-3

M3 - Article

AN - SCOPUS:0028580735

SN - 0960-894X

VL - 4

SP - 2871

EP - 2876

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

Structure activity of topoisomerase i poisons related to hoechst 33342

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this