Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents

Hsing Pang Hsieh; Jing Ping Liou; Ying Ting Lin; Neeraj Mahindroo; Jang Yang Chang; Yung Ning Yang; Shuenn Shing Chern; Uan Kang Tan; Chun Wei Chang; Tung Wei Chen; Chi Hung Lin; Ying Ying Chang; Chiung Chiu Wang

doi:10.1016/S0960-894X(02)00850-8

Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents

Hsing Pang Hsieh
, Jing Ping Liou
, Ying Ting Lin
, Neeraj Mahindroo
, Jang Yang Chang
, Yung Ning Yang
, Shuenn Shing Chern
, Uan Kang Tan
, Chun Wei Chang
, Tung Wei Chen
, Chi Hung Lin
, Ying Ying Chang
, Chiung Chiu Wang

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.

Original language	English
Pages (from-to)	101-105
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/S0960-894X(02)00850-8
Publication status	Published - Jan 6 2003
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0960-894X(02)00850-8

Cite this

Hsieh, H. P., Liou, J. P., Lin, Y. T., Mahindroo, N., Chang, J. Y., Yang, Y. N., Chern, S. S., Tan, U. K., Chang, C. W., Chen, T. W., Lin, C. H., Chang, Y. Y., & Wang, C. C. (2003). Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents. Bioorganic and Medicinal Chemistry Letters, 13(1), 101-105. https://doi.org/10.1016/S0960-894X(02)00850-8

Hsieh, HP, Liou, JP, Lin, YT, Mahindroo, N, Chang, JY, Yang, YN, Chern, SS, Tan, UK, Chang, CW, Chen, TW, Lin, CH, Chang, YY & Wang, CC 2003, 'Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents', Bioorganic and Medicinal Chemistry Letters, vol. 13, no. 1, pp. 101-105. https://doi.org/10.1016/S0960-894X(02)00850-8

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title = "Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents",

abstract = "Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.",

author = "Hsieh, \{Hsing Pang\} and Liou, \{Jing Ping\} and Lin, \{Ying Ting\} and Neeraj Mahindroo and Chang, \{Jang Yang\} and Yang, \{Yung Ning\} and Chern, \{Shuenn Shing\} and Tan, \{Uan Kang\} and Chang, \{Chun Wei\} and Chen, \{Tung Wei\} and Lin, \{Chi Hung\} and Chang, \{Ying Ying\} and Wang, \{Chiung Chiu\}",

note = "Funding Information: This work was financially supported by National Health Research Institutes, Taiwan, Republic of China. The authors are grateful to Ms. Edith Hsiao-Wen Chu and Ms. Shiau-Fen Jung for their administrative supports. ",

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doi = "10.1016/S0960-894X(02)00850-8",

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T1 - Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents

AU - Hsieh, Hsing Pang

AU - Liou, Jing Ping

AU - Lin, Ying Ting

AU - Mahindroo, Neeraj

AU - Chang, Jang Yang

AU - Yang, Yung Ning

AU - Chern, Shuenn Shing

AU - Tan, Uan Kang

AU - Chang, Chun Wei

AU - Chen, Tung Wei

AU - Lin, Chi Hung

AU - Chang, Ying Ying

AU - Wang, Chiung Chiu

N1 - Funding Information: This work was financially supported by National Health Research Institutes, Taiwan, Republic of China. The authors are grateful to Ms. Edith Hsiao-Wen Chu and Ms. Shiau-Fen Jung for their administrative supports.

PY - 2003/1/6

Y1 - 2003/1/6

N2 - Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.

AB - Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.

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DO - 10.1016/S0960-894X(02)00850-8

M3 - Article

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AN - SCOPUS:10744225059

SN - 0960-894X

VL - 13

SP - 101

EP - 105

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents

Abstract

ASJC Scopus subject areas

UN SDGs

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