Structural insights into RbmA, a biofilm scaffolding protein of V. cholerae

Manuel Maestre-Reyna, Wen Jin Wu, Andrew H.J. Wang

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


V. cholerae can form sessile biofilms associated with abiotic surfaces, cyanobacteria, zoo-plankton, mollusks, or crustaceans. Along with the vibrio polysaccharide, secreted proteins of the rbm gene cluster are key to the biofilm ultrastructure. Here we provide a thorough structural characterization of RbmA, a protein involved in mediating cellcell and cell-biofilm contacts. We correlate our structural findings with initial ligand specificity screening results, NMR protein-ligand interaction analysis, and complement our results with a full biocomputational study.

Original languageEnglish
Article numbere82458
JournalPLoS ONE
Issue number12
Publication statusPublished - Dec 5 2013
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • General


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