TY - JOUR
T1 - Structural characteristics and antioxidative capability of the soluble polysaccharides present in dictyophora indusiata (Vent. Ex Pers.) fish phallaceae
AU - Hsieh, Chiu Lan
AU - Ker, Yaw Bee
AU - Chen, Kuan Chou
AU - Peng, Chiung Chi
AU - Peng, Robert Y.
PY - 2011
Y1 - 2011
N2 - Dictyophora indusiata (Vent. ex Pers.) Fish Phallaceae (Chinese name Zhu-Sn, the bamboo fungi) has been used as a medicinal mushroom to treat many inflammatory, gastric and neural diseases since 618AD in China. We hypothesize that the soluble polysaccharides (SP) present in D. indusiata and their monosaccharide profiles can act as an important role affecting the antioxidative capability, which in turn would influence the biological activity involving anti-inflammatory, immune enhancing and anticancer. We obtained six SP fractions and designated them as D1, a galactoglucan; D2, a galactan; D3, the isoelectrically precipitated riboglucan from 2% NaOH; D4, a myoinositol; D5 and D6, the mannogalactans. The total SP accounted for 37.44% w/w, their molecular weight (MW) ranged within 8014656kDa. D3, having the smallest MW 801kDa, exhibited the most potent scavenging effect against the diphenyl-picrylhydrazyl, OH(), and O 2 radicals, yielding IC50 values 0.11, 1.02 and 0.64mgmL(1), respectively. Thus we have confirmed our hypothesis that the bioactivity of D. indusiata is related in majority, if not entirely, to its soluble polysaccharide type regarding the MW and monosaccharide profiles.
AB - Dictyophora indusiata (Vent. ex Pers.) Fish Phallaceae (Chinese name Zhu-Sn, the bamboo fungi) has been used as a medicinal mushroom to treat many inflammatory, gastric and neural diseases since 618AD in China. We hypothesize that the soluble polysaccharides (SP) present in D. indusiata and their monosaccharide profiles can act as an important role affecting the antioxidative capability, which in turn would influence the biological activity involving anti-inflammatory, immune enhancing and anticancer. We obtained six SP fractions and designated them as D1, a galactoglucan; D2, a galactan; D3, the isoelectrically precipitated riboglucan from 2% NaOH; D4, a myoinositol; D5 and D6, the mannogalactans. The total SP accounted for 37.44% w/w, their molecular weight (MW) ranged within 8014656kDa. D3, having the smallest MW 801kDa, exhibited the most potent scavenging effect against the diphenyl-picrylhydrazyl, OH(), and O 2 radicals, yielding IC50 values 0.11, 1.02 and 0.64mgmL(1), respectively. Thus we have confirmed our hypothesis that the bioactivity of D. indusiata is related in majority, if not entirely, to its soluble polysaccharide type regarding the MW and monosaccharide profiles.
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U2 - 10.1093/ecam/neq041
DO - 10.1093/ecam/neq041
M3 - Article
C2 - 21799678
AN - SCOPUS:80052723845
SN - 1741-427X
VL - 2011
JO - Evidence-based Complementary and Alternative Medicine
JF - Evidence-based Complementary and Alternative Medicine
M1 - 396013
ER -