"Chemical Equation Presented" Two loops were found to move inward toward the αfucosidase active site to produce a closed conformation of complexes with inhibitors with increasing Ki values from the micro- to nanomolar range. Although no further conformational changes in the two loops are observed for inhibitors with sub-nanomolar Ki values, the loops are additionally stabilized by hydrogen bonds and hydrophobic interactions.
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - Jan 8 2010|
- Slow binding
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