Structural basis of α-fucosidase inhibition by iminocyclitols with K_i values in the micro- to picomolar range

"Chemical Equation Presented" Two loops were found to move inward toward the αfucosidase active site to produce a closed conformation of complexes with inhibitors with increasing K_i values from the micro- to nanomolar range. Although no further conformational changes in the two loops are observed for inhibitors with sub-nanomolar K_i values, the loops are additionally stabilized by hydrogen bonds and hydrophobic interactions.