Abstract
"Chemical Equation Presented" Two loops were found to move inward toward the αfucosidase active site to produce a closed conformation of complexes with inhibitors with increasing Ki values from the micro- to nanomolar range. Although no further conformational changes in the two loops are observed for inhibitors with sub-nanomolar Ki values, the loops are additionally stabilized by hydrogen bonds and hydrophobic interactions.
Original language | English |
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Pages (from-to) | 337-340 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 49 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jan 8 2010 |
Externally published | Yes |
Keywords
- Fucosidases
- Iminocyclitols
- Inhibitors
- Slow binding
ASJC Scopus subject areas
- Catalysis
- General Chemistry