Stromal-epithelial interaction in prostate cancer progression

Leland W K Chung, Wen Chin Huang, Shian Ying Sung, Daqing Wu, Valerie Odero-Marah, Takeo Nomura, Katsumi Shigemura, Tohru Miyagi, Seogil Seo, Chumeng Shi, Joe Molitierno, James Elmore, Cynthia Anderson, Shuji Isotani, Magnus Edlund, Chia Ling Hsieh, Ruoxiang Wang, Bahig Shehata, Haiyen E. Zhau

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)


Cancer is not a single-cell disease, and its existence and behavior are constantly modulated by the host. Cancer gene expression and genetics are also highly dynamic and are regulated epigenetically by the host through gene-environment interaction. In this article, we describe the molecular pathways leading to an unusual property of cancer cells: the ability to mimic the host microenvironment and, in particular, the characteristics of osteomimicry and vasculogenic mimicry, which are likely to be regulated by soluble and insoluble factors in the tumor-adjacent microenvironment. We also discuss the importance of host inflammatory and stem cells that contribute to the growth and survival of cancer cells. By understanding the salient features of cancer-host interaction, novel therapeutics might be developed to target the cancer and its host in the treatment of lethal prostate cancer metastases.

Original languageEnglish
Pages (from-to)162-170
Number of pages9
JournalClinical Genitourinary Cancer
Issue number2
Publication statusPublished - 2006
Externally publishedYes


  • Androgen-independent progression
  • Bone metastases
  • Cell signaling
  • Epithelial to mesenchymal transition
  • Extracellular matrices
  • Growth factors
  • Inflammation
  • Osteomimicry
  • Stem cells
  • Tumor stromal interaction

ASJC Scopus subject areas

  • Oncology
  • Urology


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