Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems

Yu Jung Lin; Fwu Long Mi; Po Yen Lin; Yang Bao Miao; Tringyo Huang; Kuan Hung Chen; Chiung Tong Chen; Yen Chang; Hsing Wen Sung

doi:10.1016/j.addr.2018.12.001

Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems

Yu Jung Lin, Fwu Long Mi, Po Yen Lin, Yang Bao Miao, Tringyo Huang, Kuan Hung Chen, Chiung Tong Chen, Yen Chang, Hsing Wen Sung

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The encapsulation of insulin in micro- or nanodelivery systems may eliminate the need for frequent subcutaneous injections, improving the quality of life of diabetic patients. Formulations for oral, intranasal, pulmonary, subcutaneous, and transdermal administration have been developed. The use of stimuli-responsive polymeric carriers that can release the encapsulated drug in response to changes of the environmental stimuli or external activation enables the design of less invasive or non-invasive systems for smart insulin delivery from depots in the body. This article will look at strategies for the development of responsive delivery systems and the future meeting of the demands of new modes of insulin delivery.

Original language	English
Pages (from-to)	71-82
Number of pages	12
Journal	Advanced Drug Delivery Reviews
Volume	139
DOIs	https://doi.org/10.1016/j.addr.2018.12.001
Publication status	Published - Jan 15 2019

Keywords

Alternative routes
Diabetes mellitus
Glucose sensing
Insulin delivery
Stimuli-responsiveness

ASJC Scopus subject areas

Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.addr.2018.12.001

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title = "Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems",

abstract = "The encapsulation of insulin in micro- or nanodelivery systems may eliminate the need for frequent subcutaneous injections, improving the quality of life of diabetic patients. Formulations for oral, intranasal, pulmonary, subcutaneous, and transdermal administration have been developed. The use of stimuli-responsive polymeric carriers that can release the encapsulated drug in response to changes of the environmental stimuli or external activation enables the design of less invasive or non-invasive systems for smart insulin delivery from depots in the body. This article will look at strategies for the development of responsive delivery systems and the future meeting of the demands of new modes of insulin delivery.",

keywords = "Alternative routes, Diabetes mellitus, Glucose sensing, Insulin delivery, Stimuli-responsiveness",

author = "Lin, {Yu Jung} and Mi, {Fwu Long} and Lin, {Po Yen} and Miao, {Yang Bao} and Tringyo Huang and Chen, {Kuan Hung} and Chen, {Chiung Tong} and Yen Chang and Sung, {Hsing Wen}",

note = "Funding Information: The authors would like to thank the Ministry of Science and Technology ( MOST 107-2119-M-007-016 ) and the Ministry of Education ( MOE 107QR001I5 ) of Taiwan, ROC for financially supporting this research. Funding Information: The authors would like to thank the Ministry of Science and Technology (MOST 107-2119-M-007-016) and the Ministry of Education (MOE 107QR001I5) of Taiwan, ROC for financially supporting this research. Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

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doi = "10.1016/j.addr.2018.12.001",

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AU - Lin, Yu Jung

AU - Mi, Fwu Long

AU - Lin, Po Yen

AU - Miao, Yang Bao

AU - Huang, Tringyo

AU - Chen, Kuan Hung

AU - Chen, Chiung Tong

AU - Chang, Yen

AU - Sung, Hsing Wen

N1 - Funding Information: The authors would like to thank the Ministry of Science and Technology ( MOST 107-2119-M-007-016 ) and the Ministry of Education ( MOE 107QR001I5 ) of Taiwan, ROC for financially supporting this research. Funding Information: The authors would like to thank the Ministry of Science and Technology (MOST 107-2119-M-007-016) and the Ministry of Education (MOE 107QR001I5) of Taiwan, ROC for financially supporting this research. Publisher Copyright: © 2018 Elsevier B.V.

PY - 2019/1/15

Y1 - 2019/1/15

N2 - The encapsulation of insulin in micro- or nanodelivery systems may eliminate the need for frequent subcutaneous injections, improving the quality of life of diabetic patients. Formulations for oral, intranasal, pulmonary, subcutaneous, and transdermal administration have been developed. The use of stimuli-responsive polymeric carriers that can release the encapsulated drug in response to changes of the environmental stimuli or external activation enables the design of less invasive or non-invasive systems for smart insulin delivery from depots in the body. This article will look at strategies for the development of responsive delivery systems and the future meeting of the demands of new modes of insulin delivery.

AB - The encapsulation of insulin in micro- or nanodelivery systems may eliminate the need for frequent subcutaneous injections, improving the quality of life of diabetic patients. Formulations for oral, intranasal, pulmonary, subcutaneous, and transdermal administration have been developed. The use of stimuli-responsive polymeric carriers that can release the encapsulated drug in response to changes of the environmental stimuli or external activation enables the design of less invasive or non-invasive systems for smart insulin delivery from depots in the body. This article will look at strategies for the development of responsive delivery systems and the future meeting of the demands of new modes of insulin delivery.

KW - Alternative routes

KW - Diabetes mellitus

KW - Glucose sensing

KW - Insulin delivery

KW - Stimuli-responsiveness

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Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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