Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly

Dao Le; Friederike Wagner; Masanari Takamiya; I-Lun Hsiao; Gabriela Gil Alvaradejo; Uwe Strähle; Carsten Weiss; Guillaume Delaittre

doi:10.1039/c9cc00407f

Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly

Dao Le
, Friederike Wagner
, Masanari Takamiya
, I-Lun Hsiao
, Gabriela Gil Alvaradejo
, Uwe Strähle
, Carsten Weiss
, Guillaume Delaittre

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

We report the synthesis of poly(2-ethyl-2-oxazoline)-based (PEtOx) nanoobjects by polymerization-induced self-assembly (PISA). First, well-defined PEtOx macromolecular chain transfer agents were synthesized by cationic ring-opening polymerization and click chemistry. The photoinitiated PISA of 2-hydroxypropyl methacrylate mediated by these PEtOx produced nanoobjects spanning the full range of core-shell morphologies. The nanoparticles exhibited high biocompatibility and stealth properties in vitro or in vivo, as well as thermoresponsive behavior.

Original language	English
Pages (from-to)	3741-3744
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	26
Early online date	Mar 12 2019
DOIs	https://doi.org/10.1039/c9cc00407f
Publication status	Published - 2019

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c9cc00407f

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abstract = "We report the synthesis of poly(2-ethyl-2-oxazoline)-based (PEtOx) nanoobjects by polymerization-induced self-assembly (PISA). First, well-defined PEtOx macromolecular chain transfer agents were synthesized by cationic ring-opening polymerization and click chemistry. The photoinitiated PISA of 2-hydroxypropyl methacrylate mediated by these PEtOx produced nanoobjects spanning the full range of core-shell morphologies. The nanoparticles exhibited high biocompatibility and stealth properties in vitro or in vivo, as well as thermoresponsive behavior.",

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AU - Le, Dao

AU - Wagner, Friederike

AU - Takamiya, Masanari

AU - Hsiao, I-Lun

AU - Gil Alvaradejo, Gabriela

AU - Strähle, Uwe

AU - Weiss, Carsten

AU - Delaittre, Guillaume

PY - 2019

Y1 - 2019

N2 - We report the synthesis of poly(2-ethyl-2-oxazoline)-based (PEtOx) nanoobjects by polymerization-induced self-assembly (PISA). First, well-defined PEtOx macromolecular chain transfer agents were synthesized by cationic ring-opening polymerization and click chemistry. The photoinitiated PISA of 2-hydroxypropyl methacrylate mediated by these PEtOx produced nanoobjects spanning the full range of core-shell morphologies. The nanoparticles exhibited high biocompatibility and stealth properties in vitro or in vivo, as well as thermoresponsive behavior.

AB - We report the synthesis of poly(2-ethyl-2-oxazoline)-based (PEtOx) nanoobjects by polymerization-induced self-assembly (PISA). First, well-defined PEtOx macromolecular chain transfer agents were synthesized by cationic ring-opening polymerization and click chemistry. The photoinitiated PISA of 2-hydroxypropyl methacrylate mediated by these PEtOx produced nanoobjects spanning the full range of core-shell morphologies. The nanoparticles exhibited high biocompatibility and stealth properties in vitro or in vivo, as well as thermoresponsive behavior.

UR - https://www.scopus.com/pages/publications/85063549704

UR - https://www.scopus.com/pages/publications/85063549704#tab=citedBy

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SN - 1359-7345

VL - 55

SP - 3741

EP - 3744

JO - Chemical Communications

JF - Chemical Communications

IS - 26

ER -

Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly

Abstract

ASJC Scopus subject areas

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