Stimulation of prostaglandin E2 biosynthesis by estradiol in rat kidneys

W. C. Chang

Stimulation of prostaglandin E₂ biosynthesis by estradiol in rat kidneys

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of estradiol administration on renal prostaglandin (PG) E₂ biosynthetic activity in rats was studied. A specific radioimmunoassay for PGE₂ was developed and applied in the quantitation of PGE₂ biosynthesis in kidney. Conversion of exogenous arachidonic acid into PGE₂ by renal microsomal fraction was assayed. Formation of PGE₂ was linear in fashion up to 5 min incubation at 37°C, and linear in fashion up to 3.5 mg of microsome used as enzyme source. The renal biosynthesis of PGE₂ was significantly increased by estradiol treatment.

Original language	English
Pages (from-to)	159-163
Number of pages	5
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	33
Issue number	3
Publication status	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Clinical Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "The effect of estradiol administration on renal prostaglandin (PG) E2 biosynthetic activity in rats was studied. A specific radioimmunoassay for PGE2 was developed and applied in the quantitation of PGE2 biosynthesis in kidney. Conversion of exogenous arachidonic acid into PGE2 by renal microsomal fraction was assayed. Formation of PGE2 was linear in fashion up to 5 min incubation at 37°C, and linear in fashion up to 3.5 mg of microsome used as enzyme source. The renal biosynthesis of PGE2 was significantly increased by estradiol treatment.",

author = "Chang, {W. C.}",

year = "1988",

language = "English",

volume = "33",

pages = "159--163",

journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",

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T1 - Stimulation of prostaglandin E2 biosynthesis by estradiol in rat kidneys

AU - Chang, W. C.

PY - 1988

Y1 - 1988

N2 - The effect of estradiol administration on renal prostaglandin (PG) E2 biosynthetic activity in rats was studied. A specific radioimmunoassay for PGE2 was developed and applied in the quantitation of PGE2 biosynthesis in kidney. Conversion of exogenous arachidonic acid into PGE2 by renal microsomal fraction was assayed. Formation of PGE2 was linear in fashion up to 5 min incubation at 37°C, and linear in fashion up to 3.5 mg of microsome used as enzyme source. The renal biosynthesis of PGE2 was significantly increased by estradiol treatment.

AB - The effect of estradiol administration on renal prostaglandin (PG) E2 biosynthetic activity in rats was studied. A specific radioimmunoassay for PGE2 was developed and applied in the quantitation of PGE2 biosynthesis in kidney. Conversion of exogenous arachidonic acid into PGE2 by renal microsomal fraction was assayed. Formation of PGE2 was linear in fashion up to 5 min incubation at 37°C, and linear in fashion up to 3.5 mg of microsome used as enzyme source. The renal biosynthesis of PGE2 was significantly increased by estradiol treatment.

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AN - SCOPUS:0023819991

SN - 0952-3278

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JF - Prostaglandins Leukotrienes and Essential Fatty Acids

IS - 3

ER -

Stimulation of prostaglandin E₂ biosynthesis by estradiol in rat kidneys

Abstract

ASJC Scopus subject areas

UN SDGs

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