Stimulation of 12-lipoxygenase activity in rat platelets by 17β-estradiol

Wen Chang Chang, Junko Nakao, Hajime Orimo, Hsin Hsiung Tai, Sei Itsu Murota

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


The effects of estradiol on the endogenous fatty acid (specifically, arachidonic acid) composition of cellular phospholipid fractions and the 12-lipoxygenase activity in rat platelets in vivo were studied. Estradiol had no significant effect on the endogenous fatty acid composition of cellular phospholipid fractions. However, estradiol significantly increased 12-lipoxygenase activity in platelets in a dose-dependent manner. The stimulatory effect of estradiol on platelet lipoxygenase was blocked by the anti-estrogen nafoxidine hydrochloride which was injected simultaneously together with estradiol in vivo, suggesting that the effect in target cells was due directly to estradiol.

Original languageEnglish
Pages (from-to)2633-2638
Number of pages6
JournalBiochemical Pharmacology
Issue number16
Publication statusPublished - Aug 15 1982
Externally publishedYes


  • 12-HPETE
  • 12-l-hydoxy-5,8,10,14-eicosatetraenoic acid
  • 12-l-hydroperoxy-5,8,10,14-eicosatetraenoic acid
  • 12-l-hydroxy-5,8,10-heptadecatrienoic acid
  • 2-HETE
  • GSH
  • HHT
  • and GLC
  • gas-liquid chromtography
  • reduced glugatione

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology


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