Stimulation by prostaglandin F2α of acidic glycosaminoglycan production in cultured fibroblasts

Wen Chang Chang; Midori Abe; Sei itsu Murota

doi:10.1016/0090-6980(77)90042-9

Stimulation by prostaglandin F_2α of acidic glycosaminoglycan production in cultured fibroblasts

Wen Chang Chang, Midori Abe, Sei itsu Murota

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The effect of PGF2α on the synthesis of hexosamine-containing substances (acidic glycosaminoglycans and glycoproteins) was studied in cultured fibroblasts derived from a rat carrageenin granuloma. Treatment with PGF2α ranging from 0.01 μg/ml to 20 μg/ml resulted in a significant increase of the production of these macromolecules by the cells. The stimulatory effect was found significant even at the low concentration of 10 ng/ml, and could be seen as early as 3h after exposure to PGF2α. The hexosamine-containing substances increased by PGF2α revealed that 80% of the increase was due to acidic glycosaminoglycans and the rest was due to glycoproteins.

Original language	English
Pages (from-to)	55-63
Number of pages	9
Journal	Prostaglandins
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/0090-6980(77)90042-9
Publication status	Published - Jan 1977
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Endocrinology

Access to Document

10.1016/0090-6980(77)90042-9

Cite this

@article{cf1de59afdda4443a53e9ca46793180d,

title = "Stimulation by prostaglandin F2α of acidic glycosaminoglycan production in cultured fibroblasts",

abstract = "The effect of PGF2α on the synthesis of hexosamine-containing substances (acidic glycosaminoglycans and glycoproteins) was studied in cultured fibroblasts derived from a rat carrageenin granuloma. Treatment with PGF2α ranging from 0.01 μg/ml to 20 μg/ml resulted in a significant increase of the production of these macromolecules by the cells. The stimulatory effect was found significant even at the low concentration of 10 ng/ml, and could be seen as early as 3h after exposure to PGF2α. The hexosamine-containing substances increased by PGF2α revealed that 80% of the increase was due to acidic glycosaminoglycans and the rest was due to glycoproteins.",

author = "Chang, {Wen Chang} and Midori Abe and Murota, {Sei itsu}",

year = "1977",

month = jan,

doi = "10.1016/0090-6980(77)90042-9",

language = "English",

volume = "13",

pages = "55--63",

journal = "Prostaglandins",

issn = "0090-6980",

publisher = "Elsevier BV",

number = "1",

}

TY - JOUR

T1 - Stimulation by prostaglandin F2α of acidic glycosaminoglycan production in cultured fibroblasts

AU - Chang, Wen Chang

AU - Abe, Midori

AU - Murota, Sei itsu

PY - 1977/1

Y1 - 1977/1

N2 - The effect of PGF2α on the synthesis of hexosamine-containing substances (acidic glycosaminoglycans and glycoproteins) was studied in cultured fibroblasts derived from a rat carrageenin granuloma. Treatment with PGF2α ranging from 0.01 μg/ml to 20 μg/ml resulted in a significant increase of the production of these macromolecules by the cells. The stimulatory effect was found significant even at the low concentration of 10 ng/ml, and could be seen as early as 3h after exposure to PGF2α. The hexosamine-containing substances increased by PGF2α revealed that 80% of the increase was due to acidic glycosaminoglycans and the rest was due to glycoproteins.

AB - The effect of PGF2α on the synthesis of hexosamine-containing substances (acidic glycosaminoglycans and glycoproteins) was studied in cultured fibroblasts derived from a rat carrageenin granuloma. Treatment with PGF2α ranging from 0.01 μg/ml to 20 μg/ml resulted in a significant increase of the production of these macromolecules by the cells. The stimulatory effect was found significant even at the low concentration of 10 ng/ml, and could be seen as early as 3h after exposure to PGF2α. The hexosamine-containing substances increased by PGF2α revealed that 80% of the increase was due to acidic glycosaminoglycans and the rest was due to glycoproteins.

UR - http://www.scopus.com/inward/record.url?scp=0017367824&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017367824&partnerID=8YFLogxK

U2 - 10.1016/0090-6980(77)90042-9

DO - 10.1016/0090-6980(77)90042-9

M3 - Article

C2 - 841107

AN - SCOPUS:0017367824

SN - 0090-6980

VL - 13

SP - 55

EP - 63

JO - Prostaglandins

JF - Prostaglandins

IS - 1

ER -

Stimulation by prostaglandin F_2α of acidic glycosaminoglycan production in cultured fibroblasts

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this