Steroid use in sepsis-induced conjugated hyperbilirubinemia: report of one case

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We report a girl with acute lymphoblastic leukemia who developed severe conjugated hyperbilirubinemia (total bilirubin 34.32 mg/dl, direct bilirubin 26.94 mg/dl) following gram-negative (Escherichia coli ) sepsis. Despite broad-spectrum antibiotics, her hyperbilirubinemia progressed. Her mental status deteriorated and steroid therapy (hydrocortisone 8 mg/kg/d) was initiated. Her condition then recovered rapidly. Based on our findings, we suggest that steroid may help to treat progressive conjugated hyperbilirubinemia due to gram-negative sepsis.

Original languageEnglish
Pages (from-to)146-8
Number of pages3
JournalActa Paediatrica Sinica
Issue number3
Publication statusPublished - 2007


  • Bacteremia/complications
  • Child
  • Escherichia coli Infections/complications
  • Female
  • Humans
  • Hydrocortisone/therapeutic use
  • Hyperbilirubinemia/drug therapy
  • Parenteral Nutrition, Total


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