Statin Use and Influenza Vaccine Effectiveness in Persons >65 Years of Age, Taiwan

Lung Wen Tsai, Yung Tai Chen, Chia Jen Shih, Shuo Ming Ou, Pei Wen Chao, Shih Hsiu Lo

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Debates on whether statin use reduces the effectiveness of influenza vaccines against critical illness and death among persons >65 years of age continue. We conducted a study of 9,427,392 persons >65 years of age who did and did not receive influenza vaccinations during 12 consecutive influenza seasons, 2000-01 through 2011-12. Using data from Taiwan's National Health Insurance Research Database, we performed propensity score-matching to compare vaccinated persons with unvaccinated controls. After propensity score-matching, the vaccinated group had lower risks for in-hospital death from influenza and pneumonia and for hospitalization for pneumonia and influenza, circulatory conditions, and critical illnesses compared with the unvaccinated group. We stratified the 2 groups by statin use and analyzed data by interaction analysis and saw no statistically significant difference. We found that influenza vaccine effectively reduced risks for hospitalization and death in persons >65 years of age, regardless of statin use.

Original languageEnglish
Pages (from-to)1243-1250
Number of pages8
JournalEmerging Infectious Diseases
Issue number6
Publication statusPublished - Jun 1 2020


  • critical illness
  • hospitalization
  • influenza
  • respiratory diseases
  • Taiwan
  • vaccine-preventable diseases
  • vaccines
  • viruses

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


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