Static and dynamic characteristics of cerebral blood flow during the resting state

Qihong Zou; Changwei W. Wu; Elliot A. Stein; Yufeng Zang; Yihong Yang

doi:10.1016/j.neuroimage.2009.07.006

Static and dynamic characteristics of cerebral blood flow during the resting state

Qihong Zou, Changwei W. Wu, Elliot A. Stein, Yufeng Zang, Yihong Yang

Research output: Contribution to journal › Article › peer-review

161 Citations (Scopus)

Abstract

In this study, the static and dynamic characteristics of cerebral blood flow (CBF) in the resting state were investigated using an arterial spin labeling (ASL) perfusion imaging technique. Consistent with previous PET results, static CBF measured by ASL was significantly higher in the posterior cingulate cortex (PCC), thalamus, insula/superior temporal gyrus (STG) and medial prefrontal cortex (MPFC) than the average CBF of the brain. The dynamic measurement of CBF fluctuations showed high correlation (functional connectivity) between components in the default mode network. These brain regions also had high local temporal synchrony and high fluctuation amplitude, as measured by regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) analyses. The spatial pattern of the static CBF correlated well with that of the dynamic indices. The high static and dynamic activities in the PCC, MPFC, insula/STG and thalamus suggest that these regions play a vital role in maintaining and facilitating fundamental brain functions.

Original language	English
Pages (from-to)	515-524
Number of pages	10
Journal	NeuroImage
Volume	48
Issue number	3
DOIs	https://doi.org/10.1016/j.neuroimage.2009.07.006
Publication status	Published - Nov 15 2009
Externally published	Yes

Keywords

ALFF
CBF
Dynamic
Functional connectivity
ReHo
Resting state
Static

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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10.1016/j.neuroimage.2009.07.006

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title = "Static and dynamic characteristics of cerebral blood flow during the resting state",

abstract = "In this study, the static and dynamic characteristics of cerebral blood flow (CBF) in the resting state were investigated using an arterial spin labeling (ASL) perfusion imaging technique. Consistent with previous PET results, static CBF measured by ASL was significantly higher in the posterior cingulate cortex (PCC), thalamus, insula/superior temporal gyrus (STG) and medial prefrontal cortex (MPFC) than the average CBF of the brain. The dynamic measurement of CBF fluctuations showed high correlation (functional connectivity) between components in the default mode network. These brain regions also had high local temporal synchrony and high fluctuation amplitude, as measured by regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) analyses. The spatial pattern of the static CBF correlated well with that of the dynamic indices. The high static and dynamic activities in the PCC, MPFC, insula/STG and thalamus suggest that these regions play a vital role in maintaining and facilitating fundamental brain functions.",

keywords = "ALFF, CBF, Dynamic, Functional connectivity, ReHo, Resting state, Static",

author = "Qihong Zou and Wu, {Changwei W.} and Stein, {Elliot A.} and Yufeng Zang and Yihong Yang",

note = "Funding Information: This work was supported by the Intramural Research Program of the National Institute on Drug Abuse (NIDA), National Institute of Health (NIH). The authors thank Dr. Christian F. Beckmann for providing dual regression method for ICA denoising, Dr. Xinian Zuo for preparing the vessel mask and suggestions for removing noise using ICA, and Dr. Thomas J. Ross and Dr. Yong He for helpful discussions.",

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AU - Wu, Changwei W.

AU - Stein, Elliot A.

AU - Zang, Yufeng

AU - Yang, Yihong

N1 - Funding Information: This work was supported by the Intramural Research Program of the National Institute on Drug Abuse (NIDA), National Institute of Health (NIH). The authors thank Dr. Christian F. Beckmann for providing dual regression method for ICA denoising, Dr. Xinian Zuo for preparing the vessel mask and suggestions for removing noise using ICA, and Dr. Thomas J. Ross and Dr. Yong He for helpful discussions.

PY - 2009/11/15

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N2 - In this study, the static and dynamic characteristics of cerebral blood flow (CBF) in the resting state were investigated using an arterial spin labeling (ASL) perfusion imaging technique. Consistent with previous PET results, static CBF measured by ASL was significantly higher in the posterior cingulate cortex (PCC), thalamus, insula/superior temporal gyrus (STG) and medial prefrontal cortex (MPFC) than the average CBF of the brain. The dynamic measurement of CBF fluctuations showed high correlation (functional connectivity) between components in the default mode network. These brain regions also had high local temporal synchrony and high fluctuation amplitude, as measured by regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) analyses. The spatial pattern of the static CBF correlated well with that of the dynamic indices. The high static and dynamic activities in the PCC, MPFC, insula/STG and thalamus suggest that these regions play a vital role in maintaining and facilitating fundamental brain functions.

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Static and dynamic characteristics of cerebral blood flow during the resting state

Abstract

Keywords

ASJC Scopus subject areas

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