Specific cognitive domains and frailty trajectories among older Taiwanese adults

Lalu Suprawesta, Hei Fen Hwang, Sy Jou Chen, Wen Yu Yu, Mau Roung Lin

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Objective: To investigate the associations of specific cognitive functions and with the frailty trajectory among older Taiwanese adults. Methods: At baseline, 730 community-dwelling older adults were recruited from outpatient clinics of a general hospital. Frailty status was defined using phenotype criteria. Global cognition was assessed using the modified Telephone Interview of Cognitive Status and Mini-Mental State Examination (MMSE). The Mattis Dementia Rating Scale (MDRS) and Digit Symbol Substitution Test were used to evaluate 6 cognitive domains: attention, initiation/perseveration, construction, conceptualization, memory, and processing speed. The group-based trajectory model was used to identify latent frailty trajectory groups and the multinomial logistic regression was to examine the relationships of specific cognitive functions with frailty trajectory. Results: Among 485 participants (168 men, 317 women, and mean age: 71.1 ± 5.5 years) completed 2 annual follow-up assessments, three frailty trajectory groups of improvement, no-change, and progression were identified. After adjusting for baseline frailty status, age, sex, global cognition, regular exercise habit, and number of comorbidities, higher scores on MDRS’s initiation/perseveration (odds ratio [OR] = 0.85; 95% CI = 0.75-0.95) and attention (OR = 0.63; 95% CI = 0.38-1.00), respectively, were significantly associated with lower risk of frailty progression. Conversely, no significant association was detected between MMSE or TICSM scores and frailty improvement or progression. Conclusion: Specific cognitive functions of initiation/perseveration and attention, rather than global cognition, may be more useful to predict frailty progression, thus allowing the identification of at-risk older adults.

Original languageEnglish
Pages (from-to)1488-1495
Number of pages8
JournalAging and Mental Health
Issue number8
Publication statusPublished - 2023


  • cognitive function
  • frailty
  • latent class analysis
  • older adults
  • Taiwan

ASJC Scopus subject areas

  • Phychiatric Mental Health
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


Dive into the research topics of 'Specific cognitive domains and frailty trajectories among older Taiwanese adults'. Together they form a unique fingerprint.

Cite this