Specific chromosome defect associated with human small-cell lung cancer: Deletion 3p(14-23)

J. Whang-Peng; C. S. Kao-Shan; E. C. Lee; P. A. Bunn; D. N. Carney; A. F. Gazdar; J. D. Minna

Specific chromosome defect associated with human small-cell lung cancer: Deletion 3p(14-23)

J. Whang-Peng, C. S. Kao-Shan, E. C. Lee, P. A. Bunn, D. N. Carney, A. F. Gazdar, J. D. Minna

Research output: Contribution to journal › Article › peer-review

Abstract

A specific, acquired chromosomal abnormality (deletion 3p) has been found in at least one chromosome 3 in 100 percent of the metaphases in 12 of 12 cell lines cultured from human small-cell lung cancer tissue and in 2-day tumor culture specimens from three patients. Analysis of the shortest region of overlap shows the deletion to be 3p(14-23). This specific change was not seen in five of five lung cancer cell lines other than small-cell lung cancer or in two lymphoblastoid lines cultured from cells of small-cell lung cancer patients whose tumors had the 3p deletion.

Original language	English
Pages (from-to)	181-182
Number of pages	2
Journal	Science
Volume	215
Issue number	4529
Publication status	Published - Jan 1 1982
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)
General

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title = "Specific chromosome defect associated with human small-cell lung cancer: Deletion 3p(14-23)",

abstract = "A specific, acquired chromosomal abnormality (deletion 3p) has been found in at least one chromosome 3 in 100 percent of the metaphases in 12 of 12 cell lines cultured from human small-cell lung cancer tissue and in 2-day tumor culture specimens from three patients. Analysis of the shortest region of overlap shows the deletion to be 3p(14-23). This specific change was not seen in five of five lung cancer cell lines other than small-cell lung cancer or in two lymphoblastoid lines cultured from cells of small-cell lung cancer patients whose tumors had the 3p deletion.",

author = "J. Whang-Peng and Kao-Shan, {C. S.} and Lee, {E. C.} and Bunn, {P. A.} and Carney, {D. N.} and Gazdar, {A. F.} and Minna, {J. D.}",

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AU - Whang-Peng, J.

AU - Kao-Shan, C. S.

AU - Lee, E. C.

AU - Bunn, P. A.

AU - Carney, D. N.

AU - Gazdar, A. F.

AU - Minna, J. D.

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Y1 - 1982/1/1

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AB - A specific, acquired chromosomal abnormality (deletion 3p) has been found in at least one chromosome 3 in 100 percent of the metaphases in 12 of 12 cell lines cultured from human small-cell lung cancer tissue and in 2-day tumor culture specimens from three patients. Analysis of the shortest region of overlap shows the deletion to be 3p(14-23). This specific change was not seen in five of five lung cancer cell lines other than small-cell lung cancer or in two lymphoblastoid lines cultured from cells of small-cell lung cancer patients whose tumors had the 3p deletion.

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Specific chromosome defect associated with human small-cell lung cancer: Deletion 3p(14-23)

Abstract

ASJC Scopus subject areas

UN SDGs

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