TY - JOUR
T1 - Soybean protein-derived hydrolysate affects blood pressure in spontaneously hypertensive rats
AU - Chen, Jiun Rong
AU - Yang, Suh Ching
AU - Suetsuna, Kunio
AU - Chao, Jane C.J.
PY - 2004/2
Y1 - 2004/2
N2 - The aim of this study was to investigate the inhibitory activity of angioten-sin-converting enzyme (ACE) and antihypertensive effects of soybean protein hydrolysate in spontaneously hypertensive rats (SHRs). The inhibitory activities against ACE with an IC50 of the peptidic fraction were 0.82 (casein), 0.73 (soybean protein isolate), and 0.48 mg/mL (soybean acid-precipitated protein), respectively. Peptic hydrolysate containing 1% NaCl was added to the SHRs' feed (5% of each protein hydrolysate). Systolic blood pressure of the soybean protein hydrolysate-supplemented groups were significantly lower than that of the casein hydrolysate-supplemented group in the study period. These data suggested that soybean protein hydrolysate may retard the development of hypertension in SHRs by its ACE inhibitory effect in vivo.
AB - The aim of this study was to investigate the inhibitory activity of angioten-sin-converting enzyme (ACE) and antihypertensive effects of soybean protein hydrolysate in spontaneously hypertensive rats (SHRs). The inhibitory activities against ACE with an IC50 of the peptidic fraction were 0.82 (casein), 0.73 (soybean protein isolate), and 0.48 mg/mL (soybean acid-precipitated protein), respectively. Peptic hydrolysate containing 1% NaCl was added to the SHRs' feed (5% of each protein hydrolysate). Systolic blood pressure of the soybean protein hydrolysate-supplemented groups were significantly lower than that of the casein hydrolysate-supplemented group in the study period. These data suggested that soybean protein hydrolysate may retard the development of hypertension in SHRs by its ACE inhibitory effect in vivo.
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U2 - 10.1111/j.1745-4514.2004.tb00055.x
DO - 10.1111/j.1745-4514.2004.tb00055.x
M3 - Article
AN - SCOPUS:1842631901
SN - 0145-8884
VL - 28
SP - 61
EP - 73
JO - Journal of Food Biochemistry
JF - Journal of Food Biochemistry
IS - 1
ER -