Sonogashira reaction of aryl and heteroaryl halides with terminal alkynes catalyzed by a highly efficient and recyclable nanosized MCM-41 anchored palladium bipyridyl complex

Bo Nan Lin; Shao Hsien Huang; Wei Yi Wu; Chung Yuan Mou; Fu Yu Tsai

doi:10.3390/molecules15129157

Sonogashira reaction of aryl and heteroaryl halides with terminal alkynes catalyzed by a highly efficient and recyclable nanosized MCM-41 anchored palladium bipyridyl complex

Bo Nan Lin, Shao Hsien Huang, Wei Yi Wu, Chung Yuan Mou, Fu Yu Tsai

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

A heterogeneous catalyst, nanosized MCM-41-Pd, was used to catalyze the Sonogashira coupling of aryl and heteroaryl halides with terminal alkynes in the presence of CuI and triphenylphosphine. The coupling products were obtained in high yields using low Pd loadings to 0.01 mol%, and the nanosized MCM-41-Pd catalyst was recovered by centrifugation of the reaction solution and re-used in further runs without significant loss of reactivity.

Original language	English
Pages (from-to)	9157-9173
Number of pages	17
Journal	Molecules
Volume	15
Issue number	12
DOIs	https://doi.org/10.3390/molecules15129157
Publication status	Published - Dec 2010
Externally published	Yes

Keywords

Heterogeneous catalysis
Mesoporous silica
Palladium complex
Recyclable catalyst
Sonogashira reaction

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Sonogashira reaction of aryl and heteroaryl halides with terminal alkynes catalyzed by a highly efficient and recyclable nanosized MCM-41 anchored palladium bipyridyl complex",

abstract = "A heterogeneous catalyst, nanosized MCM-41-Pd, was used to catalyze the Sonogashira coupling of aryl and heteroaryl halides with terminal alkynes in the presence of CuI and triphenylphosphine. The coupling products were obtained in high yields using low Pd loadings to 0.01 mol%, and the nanosized MCM-41-Pd catalyst was recovered by centrifugation of the reaction solution and re-used in further runs without significant loss of reactivity.",

keywords = "Heterogeneous catalysis, Mesoporous silica, Palladium complex, Recyclable catalyst, Sonogashira reaction",

author = "Lin, {Bo Nan} and Huang, {Shao Hsien} and Wu, {Wei Yi} and Mou, {Chung Yuan} and Tsai, {Fu Yu}",

year = "2010",

month = dec,

doi = "10.3390/molecules15129157",

language = "English",

volume = "15",

pages = "9157--9173",

journal = "Molecules",

issn = "1420-3049",

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T1 - Sonogashira reaction of aryl and heteroaryl halides with terminal alkynes catalyzed by a highly efficient and recyclable nanosized MCM-41 anchored palladium bipyridyl complex

AU - Lin, Bo Nan

AU - Huang, Shao Hsien

AU - Wu, Wei Yi

AU - Mou, Chung Yuan

AU - Tsai, Fu Yu

PY - 2010/12

Y1 - 2010/12

N2 - A heterogeneous catalyst, nanosized MCM-41-Pd, was used to catalyze the Sonogashira coupling of aryl and heteroaryl halides with terminal alkynes in the presence of CuI and triphenylphosphine. The coupling products were obtained in high yields using low Pd loadings to 0.01 mol%, and the nanosized MCM-41-Pd catalyst was recovered by centrifugation of the reaction solution and re-used in further runs without significant loss of reactivity.

AB - A heterogeneous catalyst, nanosized MCM-41-Pd, was used to catalyze the Sonogashira coupling of aryl and heteroaryl halides with terminal alkynes in the presence of CuI and triphenylphosphine. The coupling products were obtained in high yields using low Pd loadings to 0.01 mol%, and the nanosized MCM-41-Pd catalyst was recovered by centrifugation of the reaction solution and re-used in further runs without significant loss of reactivity.

KW - Heterogeneous catalysis

KW - Mesoporous silica

KW - Palladium complex

KW - Recyclable catalyst

KW - Sonogashira reaction

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SN - 1420-3049

VL - 15

SP - 9157

EP - 9173

JO - Molecules

JF - Molecules

IS - 12

ER -

Sonogashira reaction of aryl and heteroaryl halides with terminal alkynes catalyzed by a highly efficient and recyclable nanosized MCM-41 anchored palladium bipyridyl complex

Abstract

Keywords

ASJC Scopus subject areas

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