Sodium nonivamide acetate: A non-pungently antinociceptive capsaicin derivative with unusual anti-inflammatory properties

Jwu Mau Yang; Chao Shun Tang; Kwong Leung Yu; Yu Chiao Yang; Wen Chang Chang; Ing Jun Chen

doi:10.1016/0306-3623(95)00086-0

Sodium nonivamide acetate: A non-pungently antinociceptive capsaicin derivative with unusual anti-inflammatory properties

Jwu Mau Yang, Chao Shun Tang, Kwong Leung Yu, Yu Chiao Yang, Wen Chang Chang, Ing Jun Chen

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

1. Bradykinin-induced vascular pain in conscious rats, hyperalgesia in the rat hind paw, rat hind paw edema induced by compound 48/80 and carrageenin and dye exudation induced by intraperitoneal injection of 0.7% acetic acid in mice were all inhibited by sodium nonivamide acetate (SNA). 2. Collagen and arachidonic acid-induced rabbit platelet aggregations were inhibited by SNA and capsaicin. In human platelet microsomes, prostaglandin E₂ formation in arachidonic acid metabolite was not inhibited by SNA but was inhibited by capsaicin and indomethacin, thromboxane B₂ formation and its synthetase activity were inhibited by SNA and capsaicin. 3. In the extracellular recording, SNA could not decrease the action potential amplitude of the vagus nerve. 4. The motor activity of mice induced by caffeine (1.0 mg/kg) was inhibited by SNA and capsaicin.

Original language	English
Pages (from-to)	141-150
Number of pages	10
Journal	General Pharmacology
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/0306-3623(95)00086-0
Publication status	Published - Jan 1996
Externally published	Yes

Keywords

Adenosine
Anti-inflammatory
Antinociceptive
Bradykinin
Caffeine
Capsaicin
Motor activity

ASJC Scopus subject areas

Pharmacology

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10.1016/0306-3623(95)00086-0

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title = "Sodium nonivamide acetate: A non-pungently antinociceptive capsaicin derivative with unusual anti-inflammatory properties",

abstract = "1. Bradykinin-induced vascular pain in conscious rats, hyperalgesia in the rat hind paw, rat hind paw edema induced by compound 48/80 and carrageenin and dye exudation induced by intraperitoneal injection of 0.7% acetic acid in mice were all inhibited by sodium nonivamide acetate (SNA). 2. Collagen and arachidonic acid-induced rabbit platelet aggregations were inhibited by SNA and capsaicin. In human platelet microsomes, prostaglandin E2 formation in arachidonic acid metabolite was not inhibited by SNA but was inhibited by capsaicin and indomethacin, thromboxane B2 formation and its synthetase activity were inhibited by SNA and capsaicin. 3. In the extracellular recording, SNA could not decrease the action potential amplitude of the vagus nerve. 4. The motor activity of mice induced by caffeine (1.0 mg/kg) was inhibited by SNA and capsaicin.",

keywords = "Adenosine, Anti-inflammatory, Antinociceptive, Bradykinin, Caffeine, Capsaicin, Motor activity",

author = "Yang, {Jwu Mau} and Tang, {Chao Shun} and Yu, {Kwong Leung} and Yang, {Yu Chiao} and Chang, {Wen Chang} and Chen, {Ing Jun}",

year = "1996",

month = jan,

doi = "10.1016/0306-3623(95)00086-0",

language = "English",

volume = "27",

pages = "141--150",

journal = "General Pharmacology",

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T1 - Sodium nonivamide acetate

T2 - A non-pungently antinociceptive capsaicin derivative with unusual anti-inflammatory properties

AU - Yang, Jwu Mau

AU - Tang, Chao Shun

AU - Yu, Kwong Leung

AU - Yang, Yu Chiao

AU - Chang, Wen Chang

AU - Chen, Ing Jun

PY - 1996/1

Y1 - 1996/1

N2 - 1. Bradykinin-induced vascular pain in conscious rats, hyperalgesia in the rat hind paw, rat hind paw edema induced by compound 48/80 and carrageenin and dye exudation induced by intraperitoneal injection of 0.7% acetic acid in mice were all inhibited by sodium nonivamide acetate (SNA). 2. Collagen and arachidonic acid-induced rabbit platelet aggregations were inhibited by SNA and capsaicin. In human platelet microsomes, prostaglandin E2 formation in arachidonic acid metabolite was not inhibited by SNA but was inhibited by capsaicin and indomethacin, thromboxane B2 formation and its synthetase activity were inhibited by SNA and capsaicin. 3. In the extracellular recording, SNA could not decrease the action potential amplitude of the vagus nerve. 4. The motor activity of mice induced by caffeine (1.0 mg/kg) was inhibited by SNA and capsaicin.

AB - 1. Bradykinin-induced vascular pain in conscious rats, hyperalgesia in the rat hind paw, rat hind paw edema induced by compound 48/80 and carrageenin and dye exudation induced by intraperitoneal injection of 0.7% acetic acid in mice were all inhibited by sodium nonivamide acetate (SNA). 2. Collagen and arachidonic acid-induced rabbit platelet aggregations were inhibited by SNA and capsaicin. In human platelet microsomes, prostaglandin E2 formation in arachidonic acid metabolite was not inhibited by SNA but was inhibited by capsaicin and indomethacin, thromboxane B2 formation and its synthetase activity were inhibited by SNA and capsaicin. 3. In the extracellular recording, SNA could not decrease the action potential amplitude of the vagus nerve. 4. The motor activity of mice induced by caffeine (1.0 mg/kg) was inhibited by SNA and capsaicin.

KW - Adenosine

KW - Anti-inflammatory

KW - Antinociceptive

KW - Bradykinin

KW - Caffeine

KW - Capsaicin

KW - Motor activity

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DO - 10.1016/0306-3623(95)00086-0

M3 - Article

C2 - 8742512

AN - SCOPUS:0029969226

SN - 0306-3623

VL - 27

SP - 141

EP - 150

JO - General Pharmacology

JF - General Pharmacology

IS - 1

ER -

Sodium nonivamide acetate: A non-pungently antinociceptive capsaicin derivative with unusual anti-inflammatory properties

Abstract

Keywords

ASJC Scopus subject areas

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