Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin

Juo Han Lin; Wen Jui Lee; Han Chung Wu; Chih Hsiung Wu; Li Ching Chen; Chi Cheng Huang; Hang Lung Chang; Tzu Chun Cheng; Hui Wen Chang; Chi Tang Ho; Shih Hsin Tu; Yuan Soon Ho

doi:10.1080/19336918.2019.1568139

Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin

Juo Han Lin, Wen Jui Lee, Han Chung Wu, Chih Hsiung Wu, Li Ching Chen, Chi Cheng Huang, Hang Lung Chang, Tzu Chun Cheng, Hui Wen Chang, Chi Tang Ho, Shih Hsin Tu, Yuan Soon Ho

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The function of small G protein signalling modulators (SGSM1/2/3) in cancer remains unknown. Our findings demonstrated that SGSM2 is a plasma membrane protein that strongly interacted with E-cadherin/β-catenin. SGSM2 downregulation enhanced the phosphorylation of focal adhesion kinase (FAK; Y576/577), decreased the expression of epithelial markers such as E-cadherin, β-catenin, and Paxillin, and increased the expression of Snail and Twist-1, which reduced cell adhesion and promoted cancer cell migration. Oestrogen and fibronectin treatment was found to promote the colocalization of SGSM2 at the leading edge with phospho-FAK (Y397). The BioGRID database showed that SGSM2 potentially interacts with cytoskeleton remodelling and cell-cell junction proteins. These evidences suggest that SGSM2 plays a role in modulating cell adhesion and cytoskeleton dynamics during cancer migration.

Original language	English
Pages (from-to)	120-137
Number of pages	18
Journal	Cell Adhesion and Migration
Volume	13
Issue number	1
DOIs	https://doi.org/10.1080/19336918.2019.1568139
Publication status	Published - Feb 2019

Keywords

breast cancer
cell adhesion
E-cadherin
EMT
oestrogen receptor
SGSM

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/19336918.2019.1568139

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Lin, J. H., Lee, W. J., Wu, H. C., Wu, C. H., Chen, L. C., Huang, C. C., Chang, H. L., Cheng, T. C., Chang, H. W., Ho, C. T., Tu, S. H., & Ho, Y. S. (2019). Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin. Cell Adhesion and Migration, 13(1), 120-137. https://doi.org/10.1080/19336918.2019.1568139

Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin. / Lin, Juo Han; Lee, Wen Jui; Wu, Han Chung et al.
In: Cell Adhesion and Migration, Vol. 13, No. 1, 02.2019, p. 120-137.

Research output: Contribution to journal › Article › peer-review

Lin, JH, Lee, WJ, Wu, HC, Wu, CH, Chen, LC, Huang, CC, Chang, HL, Cheng, TC, Chang, HW, Ho, CT, Tu, SH & Ho, YS 2019, 'Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin', Cell Adhesion and Migration, vol. 13, no. 1, pp. 120-137. https://doi.org/10.1080/19336918.2019.1568139

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title = "Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin",

abstract = "The function of small G protein signalling modulators (SGSM1/2/3) in cancer remains unknown. Our findings demonstrated that SGSM2 is a plasma membrane protein that strongly interacted with E-cadherin/β-catenin. SGSM2 downregulation enhanced the phosphorylation of focal adhesion kinase (FAK; Y576/577), decreased the expression of epithelial markers such as E-cadherin, β-catenin, and Paxillin, and increased the expression of Snail and Twist-1, which reduced cell adhesion and promoted cancer cell migration. Oestrogen and fibronectin treatment was found to promote the colocalization of SGSM2 at the leading edge with phospho-FAK (Y397). The BioGRID database showed that SGSM2 potentially interacts with cytoskeleton remodelling and cell-cell junction proteins. These evidences suggest that SGSM2 plays a role in modulating cell adhesion and cytoskeleton dynamics during cancer migration.",

keywords = "breast cancer, cell adhesion, E-cadherin, EMT, oestrogen receptor, SGSM",

author = "Lin, {Juo Han} and Lee, {Wen Jui} and Wu, {Han Chung} and Wu, {Chih Hsiung} and Chen, {Li Ching} and Huang, {Chi Cheng} and Chang, {Hang Lung} and Cheng, {Tzu Chun} and Chang, {Hui Wen} and Ho, {Chi Tang} and Tu, {Shih Hsin} and Ho, {Yuan Soon}",

note = "Funding Information: This work was supported by the Health and Welfare Surcharge of Tobacco Products grant [MOHW107-TDU-B-212-114014]; the TMU Research Center of Cancer Translational Medicine from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan [none]; the Ministry of Science and Technology, Taiwan [MOST105-2320-B038-053-MY3] and [MOST106-2320-B-038-046] awarded to Dr. Ho, [MOST106-2314-B-038-053-MY3] awarded to Dr. Tu, [MOST106-2320-B038-061-MY3] awarded to Dr. Chen, and [MOST104-2314-B-038-059-MY3] awarded to Dr. Wu]; and Taipei Medical University [TMU104-AE1-B12] awarded to Dr. Chen.",

year = "2019",

month = feb,

doi = "10.1080/19336918.2019.1568139",

language = "English",

volume = "13",

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T1 - Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin

AU - Lin, Juo Han

AU - Lee, Wen Jui

AU - Wu, Han Chung

AU - Wu, Chih Hsiung

AU - Chen, Li Ching

AU - Huang, Chi Cheng

AU - Chang, Hang Lung

AU - Cheng, Tzu Chun

AU - Chang, Hui Wen

AU - Ho, Chi Tang

AU - Tu, Shih Hsin

AU - Ho, Yuan Soon

N1 - Funding Information: This work was supported by the Health and Welfare Surcharge of Tobacco Products grant [MOHW107-TDU-B-212-114014]; the TMU Research Center of Cancer Translational Medicine from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan [none]; the Ministry of Science and Technology, Taiwan [MOST105-2320-B038-053-MY3] and [MOST106-2320-B-038-046] awarded to Dr. Ho, [MOST106-2314-B-038-053-MY3] awarded to Dr. Tu, [MOST106-2320-B038-061-MY3] awarded to Dr. Chen, and [MOST104-2314-B-038-059-MY3] awarded to Dr. Wu]; and Taipei Medical University [TMU104-AE1-B12] awarded to Dr. Chen.

PY - 2019/2

Y1 - 2019/2

N2 - The function of small G protein signalling modulators (SGSM1/2/3) in cancer remains unknown. Our findings demonstrated that SGSM2 is a plasma membrane protein that strongly interacted with E-cadherin/β-catenin. SGSM2 downregulation enhanced the phosphorylation of focal adhesion kinase (FAK; Y576/577), decreased the expression of epithelial markers such as E-cadherin, β-catenin, and Paxillin, and increased the expression of Snail and Twist-1, which reduced cell adhesion and promoted cancer cell migration. Oestrogen and fibronectin treatment was found to promote the colocalization of SGSM2 at the leading edge with phospho-FAK (Y397). The BioGRID database showed that SGSM2 potentially interacts with cytoskeleton remodelling and cell-cell junction proteins. These evidences suggest that SGSM2 plays a role in modulating cell adhesion and cytoskeleton dynamics during cancer migration.

AB - The function of small G protein signalling modulators (SGSM1/2/3) in cancer remains unknown. Our findings demonstrated that SGSM2 is a plasma membrane protein that strongly interacted with E-cadherin/β-catenin. SGSM2 downregulation enhanced the phosphorylation of focal adhesion kinase (FAK; Y576/577), decreased the expression of epithelial markers such as E-cadherin, β-catenin, and Paxillin, and increased the expression of Snail and Twist-1, which reduced cell adhesion and promoted cancer cell migration. Oestrogen and fibronectin treatment was found to promote the colocalization of SGSM2 at the leading edge with phospho-FAK (Y397). The BioGRID database showed that SGSM2 potentially interacts with cytoskeleton remodelling and cell-cell junction proteins. These evidences suggest that SGSM2 plays a role in modulating cell adhesion and cytoskeleton dynamics during cancer migration.

KW - breast cancer

KW - cell adhesion

KW - E-cadherin

KW - EMT

KW - oestrogen receptor

KW - SGSM

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JO - Cell Adhesion and Migration

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Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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