Small cell lung carcinoma: Clinicopathological, immunohistochemical, and ultrastructural study

S. W. Shy, W. H. Lee, M. C. Chou, Y. S. Lai, Y. C. Tu

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Sixty-seven cases of small cell lung carcinoma (SCLA) in Tri-Service General Hospital (TSGH) during the past 16 years were studied. For patients with extensive stage of disease, the mean survival time and 2-year survival rate were 7.2 months and 3.1% versus 13.4 months and 16.7% for patients with limited stage. A better prognosis was obtained by treatment with a combination of intensive chemotherapy and radiotherapy. Immunohistochemical studies were performed by the peroxidase-antiperoxidase method. The positive rates in descending order were bombesin (80%), synaptophysin (74.3%), neurofilament (68.6%), neuron-specific enolase (60%), low molecular weight cytokeratin (54.3%), high molecular weight cytokeratin (25.7%), chromogranin-A (22.9%), adrenocorticotrophic hormone (0). Seven cases were examined and found to be ultrastructure; only 3 cases were found to contain neurosecretory granules. We emphasize that electron microscopy is not necessary as a routine diagnostic procedure, while light microscopy should be employed whenever possible; the immunohistochemical study should be considered within this context.

Original languageEnglish
Pages (from-to)146-161
Number of pages16
JournalJournal of Surgical Oncology
Issue number3
Publication statusPublished - 1990
Externally publishedYes


  • bombesin
  • chromogranin
  • cytokeratin
  • neurofilament
  • neuron-specific enolase
  • synaptophysin

ASJC Scopus subject areas

  • Oncology
  • Surgery


Dive into the research topics of 'Small cell lung carcinoma: Clinicopathological, immunohistochemical, and ultrastructural study'. Together they form a unique fingerprint.

Cite this