Sleep disturbance in adults with untreated primary brain tumors: prevalence and impact on quality of life

Pei Ching Lin, Pin Yuan Chen, Kuo Chen Wei, Jian her Lin, Mei Ru Lin, Huan Chih Wang, Hsiao Yean Chiu

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To investigate the frequency of sleep disturbance and its effects on quality of life in adults with untreated primary brain tumors. Methods: This cross-sectional study recruited 68 and 35 patients with newly diagnosed benign and malignant brain tumors, respectively. All participants completed the Chinese versions of the Athens Insomnia Scale, Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Hospital Anxiety and Depression Scale, Brief Fatigue Inventory, and EORTC-QLQ-BN20 for quality-of-life assessment. An actigraph was used to measure sleep parameters [e.g., dichotomy index (I < O)], for at least 3 consecutive days in untreated status. Results: The majority of the patients with benign and malignant tumors had meningioma (57.4%) and glioblastoma (40%), respectively. The prevalence of insomnia, poor sleep quality, and excessive daytime sleepiness was 59.2%, 77.7%, and 4.9%, respectively. The prevalence rates of sleep disturbances were not affected by tumor locations (suprasellar vs. non-suprasellar tumors) and tumor types (benign vs. malignant tumors). Only 36 participants completed actigraphy assessments (I < O = 95.4) due to having a tight schedule, actigraph malfunction, or not having the habit of wearing a wristwatch; 61% of them experienced circadian rhythm disruption (I < O ≤ 97.5). Insomnia was the only sleep parameter that significantly affected quality of life after controlling for potential confounders (B = 0.54, p = 0.03, adjusted R2 = 0.60). Conclusion: More than 60% of the patients with primary malignant and benign brain tumors experienced insomnia, poor sleep quality, and circadian rhythm disruption. Insomnia was independently correlated with quality of life in untreated status. Health-care providers can apply these findings to design effective interventions targeting sleep disturbance to improve quality of life in this population.

Original languageEnglish
Pages (from-to)201-209
Number of pages9
JournalSleep and Biological Rhythms
Volume21
Issue number2
DOIs
Publication statusPublished - Dec 10 2022

Keywords

  • Circadian rhythm
  • Primary brain tumors
  • Quality of life
  • Sleep disturbance

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Physiology
  • Neurology
  • Physiology (medical)

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