SLC12A3 Variation and Renal Function in Chinese Patients With Hypertension

Chin Chou Huang, Chia Min Chung, Chih Yu Yang, Hsin Bang Leu, Po Hsun Huang, Liang Yu Lin, Tao Cheng Wu, Shing Jong Lin, Wen Harn Pan, Jaw Wen Chen

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Objective: SLC12A3 (solute carrier family 12 member 3) gene variants are associated with diabetic nephropathy; however, their association with hypertensive nephropathy remains unknown. We aimed to investigate the association between SLC12A3 gene polymorphisms and renal function in patients with hypertension. Methods: Participants from three non-diabetic hypertensive cohorts, including young-onset hypertension (cohort 1, n = 882), treatment-naïve hypertension (cohort 2, n = 90), and follow-up cohort (cohort 3, n = 166), underwent genotyping for single nucleotide polymorphisms in SLC12A3. Renal events were defined as a >25 and >50% decline in estimated glomerular filtration rate (eGFR). Results: In cohort 1, SLC12A3 rs16963397 C/C or C/G (P = 0.005), rs13334864 C/C or C/T (P = 0.020), and rs7187932 A/A or A/G polymorphisms (P = 0.014) had higher eGFRs compared to their counterparts, with similar findings observed in cohort 2. In cohort 3, over a mean follow-up of 5.8 ± 1.7 years, participants with either SLC12A3 rs16963397 C/C or rs13334864 C/C polymorphisms had more >25 and >50% eGFR decline than their counterparts (log-rank test, P = 0.058 and P = 0.038, respectively). Cox regression analysis revealed that SLC12A3 rs16963397 C/C and rs13334864 C/C polymorphisms were significantly associated with an increased risk of >25% [hazard ratio (HR), 3.294; 95% confidence interval (CI), 1.158–9.368; P = 0.025] and >50% decline in eGFR (HR, 18.630; 95% CI, 1.529–227.005, P = 0.022) than their counterparts. Conclusion: SLC12A3 polymorphisms are associated with renal function in Chinese patients with hypertension.

Original languageEnglish
Article number863275
JournalFrontiers in Medicine
Publication statusPublished - Jun 21 2022
Externally publishedYes


  • glomerular filtration rate
  • glomerular hyperfiltration
  • hypertension
  • hypertensive nephropathy
  • SLC12A3

ASJC Scopus subject areas

  • General Medicine


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