Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles

Fang Lu; Si Han Wu; Yann Hung; Chung Yuan Mou

doi:10.1002/smll.200900005

Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles

Fang Lu, Si Han Wu, Yann Hung, Chung Yuan Mou

Research output: Contribution to journal › Article › peer-review

932 Citations (Scopus)

Abstract

A study was conducted to demonstrate the synthesis of monodisperse mesoporous silica nanoparticle (MSN) suspensions and investigate the effect of nanoparticle size on cell uptake. The MSNs were synthesized by adjusting the pH of the reaction medium, leading to a series of MSNs with uniform size ranging from 30-280 nm. The physical properties of the MSNs were characterized with various methods, such as nitrogen adsorption-desorption, transmission electron microscopy (TEM), and X-ray powder diffraction (XRD). The particle size effect on the cell uptake efficiency with human cervical cancer cells and cellular uptake of MSNs of various sizes were investigated by confocal laser scanning microscopy (CLSM). The uptake efficiencies were determined by inductively coupled plasma mass spectrometry (ICP-MS) analysis of total silicon content.

Original language	English
Pages (from-to)	1408-1413
Number of pages	6
Journal	Small
Volume	5
Issue number	12
DOIs	https://doi.org/10.1002/smll.200900005
Publication status	Published - Jun 19 2009
Externally published	Yes

Keywords

Cell uptake
Mesoporous materials
Nanoparticles
Particle size
Silica

ASJC Scopus subject areas

General Chemistry
Biotechnology
General Materials Science
Biomaterials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/smll.200900005

Cite this

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abstract = "A study was conducted to demonstrate the synthesis of monodisperse mesoporous silica nanoparticle (MSN) suspensions and investigate the effect of nanoparticle size on cell uptake. The MSNs were synthesized by adjusting the pH of the reaction medium, leading to a series of MSNs with uniform size ranging from 30-280 nm. The physical properties of the MSNs were characterized with various methods, such as nitrogen adsorption-desorption, transmission electron microscopy (TEM), and X-ray powder diffraction (XRD). The particle size effect on the cell uptake efficiency with human cervical cancer cells and cellular uptake of MSNs of various sizes were investigated by confocal laser scanning microscopy (CLSM). The uptake efficiencies were determined by inductively coupled plasma mass spectrometry (ICP-MS) analysis of total silicon content.",

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AU - Lu, Fang

AU - Wu, Si Han

AU - Hung, Yann

AU - Mou, Chung Yuan

PY - 2009/6/19

Y1 - 2009/6/19

N2 - A study was conducted to demonstrate the synthesis of monodisperse mesoporous silica nanoparticle (MSN) suspensions and investigate the effect of nanoparticle size on cell uptake. The MSNs were synthesized by adjusting the pH of the reaction medium, leading to a series of MSNs with uniform size ranging from 30-280 nm. The physical properties of the MSNs were characterized with various methods, such as nitrogen adsorption-desorption, transmission electron microscopy (TEM), and X-ray powder diffraction (XRD). The particle size effect on the cell uptake efficiency with human cervical cancer cells and cellular uptake of MSNs of various sizes were investigated by confocal laser scanning microscopy (CLSM). The uptake efficiencies were determined by inductively coupled plasma mass spectrometry (ICP-MS) analysis of total silicon content.

AB - A study was conducted to demonstrate the synthesis of monodisperse mesoporous silica nanoparticle (MSN) suspensions and investigate the effect of nanoparticle size on cell uptake. The MSNs were synthesized by adjusting the pH of the reaction medium, leading to a series of MSNs with uniform size ranging from 30-280 nm. The physical properties of the MSNs were characterized with various methods, such as nitrogen adsorption-desorption, transmission electron microscopy (TEM), and X-ray powder diffraction (XRD). The particle size effect on the cell uptake efficiency with human cervical cancer cells and cellular uptake of MSNs of various sizes were investigated by confocal laser scanning microscopy (CLSM). The uptake efficiencies were determined by inductively coupled plasma mass spectrometry (ICP-MS) analysis of total silicon content.

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KW - Mesoporous materials

KW - Nanoparticles

KW - Particle size

KW - Silica

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Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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