TY - JOUR
T1 - Six-month nocturnal nasal positive pressure ventilation improves respiratory muscle capacity and exercise endurance in patients with chronic hypercapnic respiratory failure
AU - Chiang, Ling Ling
AU - Yu, Chih Teng
AU - Liu, Chien Ying
AU - Lo, Yu Lun
AU - Kuo, Han Pin
AU - Lin, Horng Chyuan
PY - 2006/6
Y1 - 2006/6
N2 - Background/Purpose: This study was designed to investigate the effects of 6 months of nocturnal nasal positive pressure ventilation (NNPPV) on respiratory muscle function and exercise capacity in patients with chronic respiratory failure. Methods: A prospective, randomized, controlled design was used. Twenty-nine patients with chronic respiratory failure were enrolled and allocated to either the NNPPV (n = 14) or control group (n = 15). Patients in the NNPPV group received bi-level positive pressure ventilation via nasal mask for 6 consecutive months. Arterial blood gas, respiratory muscle assessment and 6-minute walk test (6MWT) were performed before and after the 6-month NNPPV intervention. Respiratory muscle function was assessed using the variables of maximal inspiratory pressure (Pimax), maximal expiratory pressure (Pemax), and maximum voluntary ventilation (MVV). Results: Subjects in the NNPPV group showed a significant improvement in blood gas exchange and increased 6-minute walk distance (6MWD) compared to baseline and the control group. The 6MWD was significantly increased from 257.1 ± 114.1 to 345.2 ± 109.9 m (34.3%) in the NNPPV group. NNPPV also significantly improved MVV and Pimax relative to baseline. MVV was significantly increased from 19.2 ± 6.5 to 22.3 ± 7.1 L/min (16.1%) in the NNPPV group (p <0.05). Furthermore, there was a significant correlation between the magnitude of MVV improvement and 6MWD change. Conclusion: The 6-month NNPPV treatment significantly decreased the partial pressure of carbon dioxide and improved daytime respiratory muscle function, thus contributing to exercise-capacity increase in patients with chronic respiratory failure.
AB - Background/Purpose: This study was designed to investigate the effects of 6 months of nocturnal nasal positive pressure ventilation (NNPPV) on respiratory muscle function and exercise capacity in patients with chronic respiratory failure. Methods: A prospective, randomized, controlled design was used. Twenty-nine patients with chronic respiratory failure were enrolled and allocated to either the NNPPV (n = 14) or control group (n = 15). Patients in the NNPPV group received bi-level positive pressure ventilation via nasal mask for 6 consecutive months. Arterial blood gas, respiratory muscle assessment and 6-minute walk test (6MWT) were performed before and after the 6-month NNPPV intervention. Respiratory muscle function was assessed using the variables of maximal inspiratory pressure (Pimax), maximal expiratory pressure (Pemax), and maximum voluntary ventilation (MVV). Results: Subjects in the NNPPV group showed a significant improvement in blood gas exchange and increased 6-minute walk distance (6MWD) compared to baseline and the control group. The 6MWD was significantly increased from 257.1 ± 114.1 to 345.2 ± 109.9 m (34.3%) in the NNPPV group. NNPPV also significantly improved MVV and Pimax relative to baseline. MVV was significantly increased from 19.2 ± 6.5 to 22.3 ± 7.1 L/min (16.1%) in the NNPPV group (p <0.05). Furthermore, there was a significant correlation between the magnitude of MVV improvement and 6MWD change. Conclusion: The 6-month NNPPV treatment significantly decreased the partial pressure of carbon dioxide and improved daytime respiratory muscle function, thus contributing to exercise-capacity increase in patients with chronic respiratory failure.
KW - 6-minute walk test
KW - Chronic respiratory failure
KW - Nocturnal nasal positive pressure ventilation
KW - Respiratory muscle function
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U2 - 10.1016/S0929-6646(09)60185-6
DO - 10.1016/S0929-6646(09)60185-6
M3 - Article
C2 - 16801033
AN - SCOPUS:33745618933
SN - 0929-6646
VL - 105
SP - 459
EP - 467
JO - Journal of the Formosan Medical Association
JF - Journal of the Formosan Medical Association
IS - 6
ER -