TY - JOUR
T1 - Significantly lower mean serum vitamin B12 and folic acid levels and a significantly higher frequency of serum iron deficiency in younger than in older atrophic glossitis patients
AU - Wu, Yu Hsueh
AU - Wu, Yang Che
AU - Yu-Fong Chang, Julia
AU - Lee, Yi Pang
AU - Chiang, Chun Pin
AU - Sun, Andy
N1 - Funding Information:
This study was partially supported by the grants (Nos. 102-2314-B-002-125-MY3 and 105-2314-B-002-075-MY2 ) of Ministry of Science and Technology, Taiwan .
Publisher Copyright:
© 2022 Association for Dental Sciences of the Republic of China
PY - 2022
Y1 - 2022
N2 - Background/purpose:: Our previous study found that 19.0%, 16.9%, 5.3%, 2.3%, and 11.9% of 1064 atrophic glossitis (AG) patients have anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia, respectively. This study mainly evaluated the anemia, hematinic deficiencies, and hyperhomocysteinemia in 224 younger (≤50 years old) and 840 older (>50 years old) AG patients. Materials and methods: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, and homocysteine levels in 224 younger and 840 older AG patients were measured and compared with the corresponding levels in 112 younger (≤50 years old) and 420 older (>50 years old) healthy control subjects (HCSs), respectively. Results: We found that 224 younger AG patients had significantly lower mean blood Hb and serum iron levels than 112 younger HCSs. Moreover, 840 older AG patients had significantly lower mean blood Hb and serum iron levels and a significantly higher mean serum homocysteine level than 420 older HCSs. In addition, 224 younger AG patients had significantly lower mean serum vitamin B12 and folic acid levels, a lower mean serum homocysteine level (marginal significance, P = 0.056), a significantly higher frequency of serum iron deficiency, and a significantly lower frequency of hyperhomocysteinemia than 840 older AG patients. Conclusion: The younger AG patients do have significantly lower mean serum vitamin B12 and folic acid levels, a significantly higher frequency of serum iron deficiency, and a significantly lower frequency of hyperhomocysteinemia than the older AG patients.
AB - Background/purpose:: Our previous study found that 19.0%, 16.9%, 5.3%, 2.3%, and 11.9% of 1064 atrophic glossitis (AG) patients have anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia, respectively. This study mainly evaluated the anemia, hematinic deficiencies, and hyperhomocysteinemia in 224 younger (≤50 years old) and 840 older (>50 years old) AG patients. Materials and methods: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, and homocysteine levels in 224 younger and 840 older AG patients were measured and compared with the corresponding levels in 112 younger (≤50 years old) and 420 older (>50 years old) healthy control subjects (HCSs), respectively. Results: We found that 224 younger AG patients had significantly lower mean blood Hb and serum iron levels than 112 younger HCSs. Moreover, 840 older AG patients had significantly lower mean blood Hb and serum iron levels and a significantly higher mean serum homocysteine level than 420 older HCSs. In addition, 224 younger AG patients had significantly lower mean serum vitamin B12 and folic acid levels, a lower mean serum homocysteine level (marginal significance, P = 0.056), a significantly higher frequency of serum iron deficiency, and a significantly lower frequency of hyperhomocysteinemia than 840 older AG patients. Conclusion: The younger AG patients do have significantly lower mean serum vitamin B12 and folic acid levels, a significantly higher frequency of serum iron deficiency, and a significantly lower frequency of hyperhomocysteinemia than the older AG patients.
KW - Atrophic glossitis
KW - Folic acid
KW - Hemoglobin
KW - Iron
KW - Vitamin B12
KW - Younger or older patients
UR - http://www.scopus.com/inward/record.url?scp=85131787574&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85131787574&partnerID=8YFLogxK
U2 - 10.1016/j.jds.2022.05.023
DO - 10.1016/j.jds.2022.05.023
M3 - Article
AN - SCOPUS:85131787574
SN - 1991-7902
VL - 17
SP - 1487
EP - 1493
JO - Journal of Dental Sciences
JF - Journal of Dental Sciences
IS - 4
ER -