Significant elevation of CLDN16 and HAPLN3 gene expression in human breast cancer

Shou Jen Kuo; Su Yu Chien; Che Lin; Szu Erh Chan; Hsiu Ting Tsai; Dar Ren Chen

doi:10.3892/or-00000918

Significant elevation of CLDN16 and HAPLN3 gene expression in human breast cancer

Shou Jen Kuo, Su Yu Chien, Che Lin, Szu Erh Chan, Hsiu Ting Tsai, Dar Ren Chen

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Cancer development involves the destruction of tight junctions, deprivation of cell polarity, and increased cell mobility. Claudin 16 (CLDN16) is a tight junction protein and plays important roles in the maintenance of cell polarity, cellular arrangement, adhesion, paracellular transport, and ionic permeability of various epithelia. A novel link protein, HAPLN3, functions in hyaluronic acid binding and cell adhesion. Both genes are hypothesized to be related to cancer development and metastasis. The purpose of this study was to estimate the roles of the genes CLDN16 and HAPLN3 in breast cancer. A total of 146 samples were collected from breast cancer tissues and their adjacent normal breast tissues. Reverse transcription and real-time polymerase chain reaction were used to estimate gene expression levels. There were significantly increased gene expression of CLDN16 (p

Original language	English
Pages (from-to)	759-766
Number of pages	8
Journal	Oncology Reports
Volume	24
Issue number	3
DOIs	https://doi.org/10.3892/or-00000918
Publication status	Published - Sept 2010
Externally published	Yes

Keywords

Breast cancer
CLDN16
Gene expression
HAPLN3

ASJC Scopus subject areas

Cancer Research
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/or-00000918

Cite this

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title = "Significant elevation of CLDN16 and HAPLN3 gene expression in human breast cancer",

abstract = "Cancer development involves the destruction of tight junctions, deprivation of cell polarity, and increased cell mobility. Claudin 16 (CLDN16) is a tight junction protein and plays important roles in the maintenance of cell polarity, cellular arrangement, adhesion, paracellular transport, and ionic permeability of various epithelia. A novel link protein, HAPLN3, functions in hyaluronic acid binding and cell adhesion. Both genes are hypothesized to be related to cancer development and metastasis. The purpose of this study was to estimate the roles of the genes CLDN16 and HAPLN3 in breast cancer. A total of 146 samples were collected from breast cancer tissues and their adjacent normal breast tissues. Reverse transcription and real-time polymerase chain reaction were used to estimate gene expression levels. There were significantly increased gene expression of CLDN16 (p",

keywords = "Breast cancer, CLDN16, Gene expression, HAPLN3",

author = "Kuo, {Shou Jen} and Chien, {Su Yu} and Che Lin and Chan, {Szu Erh} and Tsai, {Hsiu Ting} and Chen, {Dar Ren}",

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T1 - Significant elevation of CLDN16 and HAPLN3 gene expression in human breast cancer

AU - Kuo, Shou Jen

AU - Chien, Su Yu

AU - Lin, Che

AU - Chan, Szu Erh

AU - Tsai, Hsiu Ting

AU - Chen, Dar Ren

PY - 2010/9

Y1 - 2010/9

N2 - Cancer development involves the destruction of tight junctions, deprivation of cell polarity, and increased cell mobility. Claudin 16 (CLDN16) is a tight junction protein and plays important roles in the maintenance of cell polarity, cellular arrangement, adhesion, paracellular transport, and ionic permeability of various epithelia. A novel link protein, HAPLN3, functions in hyaluronic acid binding and cell adhesion. Both genes are hypothesized to be related to cancer development and metastasis. The purpose of this study was to estimate the roles of the genes CLDN16 and HAPLN3 in breast cancer. A total of 146 samples were collected from breast cancer tissues and their adjacent normal breast tissues. Reverse transcription and real-time polymerase chain reaction were used to estimate gene expression levels. There were significantly increased gene expression of CLDN16 (p

AB - Cancer development involves the destruction of tight junctions, deprivation of cell polarity, and increased cell mobility. Claudin 16 (CLDN16) is a tight junction protein and plays important roles in the maintenance of cell polarity, cellular arrangement, adhesion, paracellular transport, and ionic permeability of various epithelia. A novel link protein, HAPLN3, functions in hyaluronic acid binding and cell adhesion. Both genes are hypothesized to be related to cancer development and metastasis. The purpose of this study was to estimate the roles of the genes CLDN16 and HAPLN3 in breast cancer. A total of 146 samples were collected from breast cancer tissues and their adjacent normal breast tissues. Reverse transcription and real-time polymerase chain reaction were used to estimate gene expression levels. There were significantly increased gene expression of CLDN16 (p

KW - Breast cancer

KW - CLDN16

KW - Gene expression

KW - HAPLN3

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Significant elevation of CLDN16 and HAPLN3 gene expression in human breast cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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