Significant elevation of CLDN16 and HAPLN3 gene expression in human breast cancer

Shou Jen Kuo, Su Yu Chien, Che Lin, Szu Erh Chan, Hsiu Ting Tsai, Dar Ren Chen

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Cancer development involves the destruction of tight junctions, deprivation of cell polarity, and increased cell mobility. Claudin 16 (CLDN16) is a tight junction protein and plays important roles in the maintenance of cell polarity, cellular arrangement, adhesion, paracellular transport, and ionic permeability of various epithelia. A novel link protein, HAPLN3, functions in hyaluronic acid binding and cell adhesion. Both genes are hypothesized to be related to cancer development and metastasis. The purpose of this study was to estimate the roles of the genes CLDN16 and HAPLN3 in breast cancer. A total of 146 samples were collected from breast cancer tissues and their adjacent normal breast tissues. Reverse transcription and real-time polymerase chain reaction were used to estimate gene expression levels. There were significantly increased gene expression of CLDN16 (p

Original languageEnglish
Pages (from-to)759-766
Number of pages8
JournalOncology Reports
Issue number3
Publication statusPublished - Sept 2010
Externally publishedYes


  • Breast cancer
  • CLDN16
  • Gene expression
  • HAPLN3

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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