Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease

Kuo Shuen Chen; Po Hui Wang; Shun Fa Yang; Ding Bang Lin; Yi Jiun Lin; Dong Yih Kuo; Long Yau Lin; Ming Tsang Wu; Chiao Wen Lin; Sheuan Lee; Ming Chih Chou; Hsiu Ting Tsai; Yih Shou Hsieh

doi:10.1515/CCLM.2008.318

Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease

Kuo Shuen Chen, Po Hui Wang, Shun Fa Yang, Ding Bang Lin, Yi Jiun Lin, Dong Yih Kuo, Long Yau Lin, Ming Tsang Wu, Chiao Wen Lin, Sheuan Lee, Ming Chih Chou, Hsiu Ting Tsai, Yih Shou Hsieh

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Background: We investigated the expressions and ratios of type 1 T helper cell (Th1) cytokines interferon-γ (IFN-γ) and interleukin-2 (IL-2), as well as type 2 T helper cell (Th2) cytokines interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13) and interleukin-10 (IL-10) in pelvic inflammatory disease (PID) patients. Methods: The human cytokine LINCOplex multiplex bead array was used to measure the plasma levels of Th1 and Th2 cytokines in 50 healthy controls, as well as in 41 PID patients before and after routine protocol treatment. Results: Significantly increased expressions of Th1 cytokine IFN-γ (p=0.004), as well as Th2 cytokine IL-5 (p=0.001), and dramatically increased IL-10 (p=0.0001), but significantly decreased expression of Th1 cytokine IL-2 (p=0.029) in PID patients were found after comparison to the control group. The ratio of IFN-γ to IL-13 showed a significant increase, but the ratios of IFN-γ to IL-10 and IL-2 to IL-10 was significantly decreased in PID patients before treatment compared to after treatment and controls. Conclusions: The results indicate that the imbalance and cross-regulation between Th1 and Th2 cytokines pathways is probably contributed to the mechanism of PID.

Original language	English
Pages (from-to)	1609-1616
Number of pages	8
Journal	Clinical Chemistry and Laboratory Medicine
Volume	46
Issue number	11
DOIs	https://doi.org/10.1515/CCLM.2008.318
Publication status	Published - Nov 1 2008
Externally published	Yes

Keywords

Interferon-γ
Interleukin-10
Pelvic inflammatory disease

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1515/CCLM.2008.318

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@article{e02d260d319642bbae49398fd6c5cebb,

title = "Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease",

abstract = "Background: We investigated the expressions and ratios of type 1 T helper cell (Th1) cytokines interferon-γ (IFN-γ) and interleukin-2 (IL-2), as well as type 2 T helper cell (Th2) cytokines interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13) and interleukin-10 (IL-10) in pelvic inflammatory disease (PID) patients. Methods: The human cytokine LINCOplex multiplex bead array was used to measure the plasma levels of Th1 and Th2 cytokines in 50 healthy controls, as well as in 41 PID patients before and after routine protocol treatment. Results: Significantly increased expressions of Th1 cytokine IFN-γ (p=0.004), as well as Th2 cytokine IL-5 (p=0.001), and dramatically increased IL-10 (p=0.0001), but significantly decreased expression of Th1 cytokine IL-2 (p=0.029) in PID patients were found after comparison to the control group. The ratio of IFN-γ to IL-13 showed a significant increase, but the ratios of IFN-γ to IL-10 and IL-2 to IL-10 was significantly decreased in PID patients before treatment compared to after treatment and controls. Conclusions: The results indicate that the imbalance and cross-regulation between Th1 and Th2 cytokines pathways is probably contributed to the mechanism of PID.",

keywords = "Interferon-γ, Interleukin-10, Pelvic inflammatory disease",

author = "Chen, {Kuo Shuen} and Wang, {Po Hui} and Yang, {Shun Fa} and Lin, {Ding Bang} and Lin, {Yi Jiun} and Kuo, {Dong Yih} and Lin, {Long Yau} and Wu, {Ming Tsang} and Lin, {Chiao Wen} and Sheuan Lee and Chou, {Ming Chih} and Tsai, {Hsiu Ting} and Hsieh, {Yih Shou}",

note = "Funding Information: This study was supported by grants from the National Science Council, Taiwan (NSC-96-2314-B-040-002) and Chung Shan Medical University, Taichung, Taiwan (CSMU-95-OMB-042).",

year = "2008",

month = nov,

day = "1",

doi = "10.1515/CCLM.2008.318",

language = "English",

volume = "46",

pages = "1609--1616",

journal = "Clinical Chemistry and Laboratory Medicine",

issn = "1434-6621",

publisher = "Walter de Gruyter GmbH & Co. KG",

number = "11",

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TY - JOUR

T1 - Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease

AU - Chen, Kuo Shuen

AU - Wang, Po Hui

AU - Yang, Shun Fa

AU - Lin, Ding Bang

AU - Lin, Yi Jiun

AU - Kuo, Dong Yih

AU - Lin, Long Yau

AU - Wu, Ming Tsang

AU - Lin, Chiao Wen

AU - Lee, Sheuan

AU - Chou, Ming Chih

AU - Tsai, Hsiu Ting

AU - Hsieh, Yih Shou

N1 - Funding Information: This study was supported by grants from the National Science Council, Taiwan (NSC-96-2314-B-040-002) and Chung Shan Medical University, Taichung, Taiwan (CSMU-95-OMB-042).

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Background: We investigated the expressions and ratios of type 1 T helper cell (Th1) cytokines interferon-γ (IFN-γ) and interleukin-2 (IL-2), as well as type 2 T helper cell (Th2) cytokines interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13) and interleukin-10 (IL-10) in pelvic inflammatory disease (PID) patients. Methods: The human cytokine LINCOplex multiplex bead array was used to measure the plasma levels of Th1 and Th2 cytokines in 50 healthy controls, as well as in 41 PID patients before and after routine protocol treatment. Results: Significantly increased expressions of Th1 cytokine IFN-γ (p=0.004), as well as Th2 cytokine IL-5 (p=0.001), and dramatically increased IL-10 (p=0.0001), but significantly decreased expression of Th1 cytokine IL-2 (p=0.029) in PID patients were found after comparison to the control group. The ratio of IFN-γ to IL-13 showed a significant increase, but the ratios of IFN-γ to IL-10 and IL-2 to IL-10 was significantly decreased in PID patients before treatment compared to after treatment and controls. Conclusions: The results indicate that the imbalance and cross-regulation between Th1 and Th2 cytokines pathways is probably contributed to the mechanism of PID.

AB - Background: We investigated the expressions and ratios of type 1 T helper cell (Th1) cytokines interferon-γ (IFN-γ) and interleukin-2 (IL-2), as well as type 2 T helper cell (Th2) cytokines interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13) and interleukin-10 (IL-10) in pelvic inflammatory disease (PID) patients. Methods: The human cytokine LINCOplex multiplex bead array was used to measure the plasma levels of Th1 and Th2 cytokines in 50 healthy controls, as well as in 41 PID patients before and after routine protocol treatment. Results: Significantly increased expressions of Th1 cytokine IFN-γ (p=0.004), as well as Th2 cytokine IL-5 (p=0.001), and dramatically increased IL-10 (p=0.0001), but significantly decreased expression of Th1 cytokine IL-2 (p=0.029) in PID patients were found after comparison to the control group. The ratio of IFN-γ to IL-13 showed a significant increase, but the ratios of IFN-γ to IL-10 and IL-2 to IL-10 was significantly decreased in PID patients before treatment compared to after treatment and controls. Conclusions: The results indicate that the imbalance and cross-regulation between Th1 and Th2 cytokines pathways is probably contributed to the mechanism of PID.

KW - Interferon-γ

KW - Interleukin-10

KW - Pelvic inflammatory disease

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U2 - 10.1515/CCLM.2008.318

DO - 10.1515/CCLM.2008.318

M3 - Article

C2 - 19012526

AN - SCOPUS:56549095508

SN - 1434-6621

VL - 46

SP - 1609

EP - 1616

JO - Clinical Chemistry and Laboratory Medicine

JF - Clinical Chemistry and Laboratory Medicine

IS - 11

ER -

Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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