Severity of spontaneous echo contrast in the jugular vein associated with ischemic stroke

Hung Yi Hsu, Yu Shan Lee, Ming Che Ou, Chih Ping Chung, Su Yi Chen, Yu Ping Ho, Han Hwa Hu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


This study evaluated the relationship between spontaneous echo contrast (SEC) in the internal jugular vein (JV), atherosclerotic markers and ischemic stroke. One hundred twenty patients with acute ischemic stroke and 120 controls were recruited. SEC score correlated with plasma level of fibrinogen (coefficient: 0.105, p=0.022), hemoglobin (coefficient: 0.122, p=0.008) and presence of JV reflux (coefficient: 0.314, p<0.001) and peak flow velocity (coefficient: -0.244, p<0.001) in the corresponding JV, but did not correlate with carotid plaque score (coefficient: 0.042, p=0.358) or intima-media thickness (coefficient: 0.067, p=0.303). Multivariate regression analysis revealed that fibrinogen level, SEC score, intima-media thickness, plaque score and history of coronary artery disease were associated with acute ischemic stroke. In conclusion, the severity of SEC in the JV might represent the tendency toward thrombogenesis in diseased cerebral circulation possibly through mechanisms other than arterial atherosclerosis.

Original languageEnglish
Pages (from-to)1427-1433
Number of pages7
JournalUltrasound in Medicine and Biology
Issue number7
Publication statusPublished - Jan 1 2014
Externally publishedYes


  • Carotid artery
  • Ischemic stroke
  • Jugular vein
  • Spontaneous echo contrast
  • Ultrasonography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics


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