Abstract
Objective. To submit serum levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) to statistical analyses to test their exact degrees of clinical usefulness as biomarkers for detecting high disease activity in ankylosing spondylitis (AS), comparing them with erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Methods. Serum levels of MMP-1, -3, -9 and TI MP-1 and -2 were measured in 42 AS patients and 20 healthy controls. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) provided the gold standard for measuring disease activity. Patients with BASDAI ≥4 were regarded as having high disease activity. The results were compared with results for a separate cohort of 41 AS patients. Results. Only MMP-3 levels were significantly higher in AS patients than in healthy controls (P
Original language | English |
---|---|
Pages (from-to) | 414-420 |
Number of pages | 7 |
Journal | Rheumatology |
Volume | 45 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2006 |
Externally published | Yes |
Keywords
- Ankylosing spondylitis
- Disease activity
- Matrix metalloproteinase
- Tissue inhibitors of metalloproteinase
ASJC Scopus subject areas
- Neuroscience(all)
- Rheumatology