Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in ankylosing spondylitis: MMP-3 is a reproducibly sensitive and specific biomarker of disease activity

C. H. Chen; K. C. Lin; D. T Y Yu; C. Yang; F. Huang; H. A. Chen; T. H. Liang; H. T. Liao; C. Y. Tsai; J. C C Wei; C. T. Chou

doi:10.1093/rheumatology/kei208

Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in ankylosing spondylitis: MMP-3 is a reproducibly sensitive and specific biomarker of disease activity

C. H. Chen, K. C. Lin, D. T Y Yu, C. Yang, F. Huang, H. A. Chen, T. H. Liang, H. T. Liao, C. Y. Tsai, J. C C Wei, C. T. Chou

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

Objective. To submit serum levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) to statistical analyses to test their exact degrees of clinical usefulness as biomarkers for detecting high disease activity in ankylosing spondylitis (AS), comparing them with erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Methods. Serum levels of MMP-1, -3, -9 and TI MP-1 and -2 were measured in 42 AS patients and 20 healthy controls. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) provided the gold standard for measuring disease activity. Patients with BASDAI ≥4 were regarded as having high disease activity. The results were compared with results for a separate cohort of 41 AS patients. Results. Only MMP-3 levels were significantly higher in AS patients than in healthy controls (P

Original language	English
Pages (from-to)	414-420
Number of pages	7
Journal	Rheumatology
Volume	45
Issue number	4
DOIs	https://doi.org/10.1093/rheumatology/kei208
Publication status	Published - Apr 2006
Externally published	Yes

Keywords

Ankylosing spondylitis
Disease activity
Matrix metalloproteinase
Tissue inhibitors of metalloproteinase

ASJC Scopus subject areas

Neuroscience(all)
Rheumatology

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10.1093/rheumatology/kei208

Cite this

Chen, C. H., Lin, K. C., Yu, D. T. Y., Yang, C., Huang, F., Chen, H. A., Liang, T. H., Liao, H. T., Tsai, C. Y., Wei, J. C. C., & Chou, C. T. (2006). Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in ankylosing spondylitis: MMP-3 is a reproducibly sensitive and specific biomarker of disease activity. Rheumatology, 45(4), 414-420. https://doi.org/10.1093/rheumatology/kei208

Chen, CH, Lin, KC, Yu, DTY, Yang, C, Huang, F, Chen, HA, Liang, TH, Liao, HT, Tsai, CY, Wei, JCC & Chou, CT 2006, 'Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in ankylosing spondylitis: MMP-3 is a reproducibly sensitive and specific biomarker of disease activity', Rheumatology, vol. 45, no. 4, pp. 414-420. https://doi.org/10.1093/rheumatology/kei208

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abstract = "Objective. To submit serum levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) to statistical analyses to test their exact degrees of clinical usefulness as biomarkers for detecting high disease activity in ankylosing spondylitis (AS), comparing them with erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Methods. Serum levels of MMP-1, -3, -9 and TI MP-1 and -2 were measured in 42 AS patients and 20 healthy controls. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) provided the gold standard for measuring disease activity. Patients with BASDAI ≥4 were regarded as having high disease activity. The results were compared with results for a separate cohort of 41 AS patients. Results. Only MMP-3 levels were significantly higher in AS patients than in healthy controls (P",

keywords = "Ankylosing spondylitis, Disease activity, Matrix metalloproteinase, Tissue inhibitors of metalloproteinase",

author = "Chen, {C. H.} and Lin, {K. C.} and Yu, {D. T Y} and C. Yang and F. Huang and Chen, {H. A.} and Liang, {T. H.} and Liao, {H. T.} and Tsai, {C. Y.} and Wei, {J. C C} and Chou, {C. T.}",

year = "2006",

month = apr,

doi = "10.1093/rheumatology/kei208",

language = "English",

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AU - Chen, C. H.

AU - Lin, K. C.

AU - Yu, D. T Y

AU - Yang, C.

AU - Huang, F.

AU - Chen, H. A.

AU - Liang, T. H.

AU - Liao, H. T.

AU - Tsai, C. Y.

AU - Wei, J. C C

AU - Chou, C. T.

PY - 2006/4

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N2 - Objective. To submit serum levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) to statistical analyses to test their exact degrees of clinical usefulness as biomarkers for detecting high disease activity in ankylosing spondylitis (AS), comparing them with erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Methods. Serum levels of MMP-1, -3, -9 and TI MP-1 and -2 were measured in 42 AS patients and 20 healthy controls. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) provided the gold standard for measuring disease activity. Patients with BASDAI ≥4 were regarded as having high disease activity. The results were compared with results for a separate cohort of 41 AS patients. Results. Only MMP-3 levels were significantly higher in AS patients than in healthy controls (P

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KW - Tissue inhibitors of metalloproteinase

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Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in ankylosing spondylitis: MMP-3 is a reproducibly sensitive and specific biomarker of disease activity

Abstract

Keywords

ASJC Scopus subject areas

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