Serum levels of the IgA isotype switch factor TGF-β1 are elevated in patients with COVID-19

Er yi Wang, Hao Chen, Bao qing Sun, Hui Wang, Hui Qi Qu, Yichuan Liu, Xi zhuo Sun, Jingchun Qu, Zhang fu Fang, Lifeng Tian, Yi feng Zeng, Shau Ku Huang, Hakon Hakonarson, Zhi gang Liu

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


We previously observed enhanced immunoglobulin A (IgA) responses in severe COVID-19, which might confer damaging effects. Given the important role of IgA in immune and inflammatory responses, the aim of this study was to investigate the dynamic response of the IgA isotype switch factor TGF-β1 in COVID-19 patients. We observed, in a total of 153 COVID-19 patients, that the serum levels of TGF-β1 were increased significantly at the early and middle stages of COVID-19, and correlated with the levels of SARS-CoV-2-specific IgA, as well as with the APACHE II score in patients with severe disease. In view of the genetic association of the TGF-β1 activator THBS3 with severe COVID-19 identified by the COVID-19 Host Genetics Initiative, this study suggests TGF-β1 may play a key role in COVID-19.

Original languageEnglish
Pages (from-to)1819-1824
Number of pages6
JournalFEBS Letters
Issue number13
Publication statusPublished - Jul 2021
Externally publishedYes


  • COVID-19
  • IgA
  • SARS-CoV-2
  • TGF-β1

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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