@article{97549ed7e6ff4682a795126e68348d60,
title = "Serum levels of the IgA isotype switch factor TGF-β1 are elevated in patients with COVID-19",
abstract = "We previously observed enhanced immunoglobulin A (IgA) responses in severe COVID-19, which might confer damaging effects. Given the important role of IgA in immune and inflammatory responses, the aim of this study was to investigate the dynamic response of the IgA isotype switch factor TGF-β1 in COVID-19 patients. We observed, in a total of 153 COVID-19 patients, that the serum levels of TGF-β1 were increased significantly at the early and middle stages of COVID-19, and correlated with the levels of SARS-CoV-2-specific IgA, as well as with the APACHE II score in patients with severe disease. In view of the genetic association of the TGF-β1 activator THBS3 with severe COVID-19 identified by the COVID-19 Host Genetics Initiative, this study suggests TGF-β1 may play a key role in COVID-19.",
keywords = "COVID-19, IgA, SARS-CoV-2, TGF-β1",
author = "Wang, {Er yi} and Hao Chen and Sun, {Bao qing} and Hui Wang and Qu, {Hui Qi} and Yichuan Liu and Sun, {Xi zhuo} and Jingchun Qu and Fang, {Zhang fu} and Lifeng Tian and Zeng, {Yi feng} and Huang, {Shau Ku} and Hakon Hakonarson and Liu, {Zhi gang}",
note = "Funding Information: This study was supported by grants from Key Projects of Shenzhen Science and Technology Plan No. JSGG20200225153031960 Shenzhen Science and Technology Project No. KQTD20170331145453160, Shenzhen Nanshan District Pioneer Group Research Funds No. LHTD20180007, National Natural Science Foundation of China (No. 81803202), COVID-19 Prevention and Control from the China Postdoctoral Science Foundation (2020T130024ZX), and Zhejiang University special scientific research funding for COVID-19 prevention and control (2020XGZX001 and 2020XGZX025). Funding Information: This study was supported by grants from Key Projects of Shenzhen Science and Technology Plan No. JSGG20200225153031960 Shenzhen Science and Technology Project No. KQTD20170331145453160, Shenzhen Nanshan District Pioneer Group Research Funds No. LHTD20180007, National Natural Science Foundation of China (No. 81803202), COVID‐19 Prevention and Control from the China Postdoctoral Science Foundation (2020T130024ZX), and Zhejiang University special scientific research funding for COVID‐19 prevention and control (2020XGZX001 and 2020XGZX025). Publisher Copyright: {\textcopyright} 2021 Federation of European Biochemical Societies.",
year = "2021",
month = jul,
doi = "10.1002/1873-3468.14104",
language = "English",
volume = "595",
pages = "1819--1824",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "13",
}