TY - JOUR
T1 - Serum cytokine level fluctuations in chemotherapy-induced myelosuppression
AU - Chen, Yuh Min
AU - Whang-Peng, Jacqueline
AU - Liu, Jacqueline Ming
AU - Kuo, Benjamin Ing Tiau
AU - Wang, Sheng Yuan
AU - Tsai, Chun Ming
AU - Perng, Reury Perng
N1 - Funding Information:
dancer Clinical Research Center, Institute of Biomedical Sciences, Academia Departments of internal Medicine and "Medical Research and Education, Veterans' School of Medicine, National Yang-Ming University, Shin-pai, Taipei
PY - 1996/1/1
Y1 - 1996/1/1
N2 - We have reported that serum granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) levels rise in patients with chemotherapy-induced myelosuppression. The aim of the present study was to determine whether other cytokines that function at different hematopoietic stages also fluctuate during chemotherapy-induced myelosuppression and whether the extent of cytokine level fluctuations correlate with myelosuppression severity. Fifteen patients participated in the study. Serum levels of stem cell factor (SCF), interleukin (IL)-1α, IL-6, IL-3, granulocyteitmacrophage CSF (GM-CSF) and G-CSF were analyzed before chemotherapy and during the myelosuppressive stage and correlations between cytokine levels and myelosuppression severity were examined. The results showed that both serum G-CSF and IL-6 levels rose in patients with chemotherapy-induced myelosuppression. The prechemotherapy serum G-CSF and IL-6 levels correlated well with their respective elevated levels during the myelosuppressive stage. The myelosuppression severity also correlated well with the extent of serum G-CSF level elevation. The serum IL-6 and G-CSF levels during the myelosuppressive stage correlated significantly. Serum SCF levels did not fluctuate significantly during myelosuppression, and IL-1, IL-3 and GM-CSF were rarely detected in serum even after chemotherapy. In the present study, the roles of IL-1α, SCF, IL-3 and GM-CSF chemotherapy-induced myelosuppression were not clear.
AB - We have reported that serum granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) levels rise in patients with chemotherapy-induced myelosuppression. The aim of the present study was to determine whether other cytokines that function at different hematopoietic stages also fluctuate during chemotherapy-induced myelosuppression and whether the extent of cytokine level fluctuations correlate with myelosuppression severity. Fifteen patients participated in the study. Serum levels of stem cell factor (SCF), interleukin (IL)-1α, IL-6, IL-3, granulocyteitmacrophage CSF (GM-CSF) and G-CSF were analyzed before chemotherapy and during the myelosuppressive stage and correlations between cytokine levels and myelosuppression severity were examined. The results showed that both serum G-CSF and IL-6 levels rose in patients with chemotherapy-induced myelosuppression. The prechemotherapy serum G-CSF and IL-6 levels correlated well with their respective elevated levels during the myelosuppressive stage. The myelosuppression severity also correlated well with the extent of serum G-CSF level elevation. The serum IL-6 and G-CSF levels during the myelosuppressive stage correlated significantly. Serum SCF levels did not fluctuate significantly during myelosuppression, and IL-1, IL-3 and GM-CSF were rarely detected in serum even after chemotherapy. In the present study, the roles of IL-1α, SCF, IL-3 and GM-CSF chemotherapy-induced myelosuppression were not clear.
KW - Granulocyte colony-stimulating factor
KW - IL-3
KW - IL-6
KW - Interleukin-1α (IL-1α)
KW - Stem cell factor
UR - http://www.scopus.com/inward/record.url?scp=0030075690&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030075690&partnerID=8YFLogxK
U2 - 10.1093/oxfordjournals.jjco.a023173
DO - 10.1093/oxfordjournals.jjco.a023173
M3 - Article
C2 - 8551662
AN - SCOPUS:0030075690
SN - 0368-2811
VL - 26
SP - 18
EP - 23
JO - Japanese Journal of Clinical Oncology
JF - Japanese Journal of Clinical Oncology
IS - 1
ER -
