Objective: To present a rare case of serous degeneration of bone marrow which resembles primary spinal tumor or bony metastasis to spine. Summary of background data: Serous degeneration of bone marrow or gelatinous marrow transformation is a rare disease characterized by focal marrow hypoplasia, fat atrophy, and accumulation of extracellular mucopolysaccharides abundant in hyaluronic acid. Few literature was reviewed and few clinical case was presented. Methods: Two cases of serous marrow transformation were reported. Results: In the first case, a 29-year-old man suffered from severe left buttock pain. Bone metastasis was impressed in radiology examinations. Percutaneous endoscopic lumbar discectomy was performed along with bone biopsy. In the second case, a 49-year-old man presented lower back pain with radiation to bilateral lower legs. Magnetic resonance imaging revealed a water-like signal lesion in sacrum. Serous marrow transformation was confirmed pathologically in both cases. Conclusion: To the best of our knowledge, a case of serous degeneration of bone marrow resembling malignancy has not been reported in the literature. In this report, two cases demonstrate serous transformation of bone marrow mimics spinal tumor.

Original languageEnglish
Pages (from-to)S80-S84
JournalEuropean Spine Journal
Publication statusPublished - Sept 21 2017


  • Gelatinous marrow transformation
  • Magnetic resonance imaging
  • Serous atrophy
  • Serous degeneration

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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