TY - JOUR
T1 - Serotype competence and penicillin resistance in Streptococcus pneumoniae
AU - Hsieh, Yu Chia
AU - Wang, Jin Town
AU - Lee, Wen Sen
AU - Hsueh, Po Ren
AU - Shao, Pei Lan
AU - Chang, Luan Yin
AU - Lu, Chun Yi
AU - Lee, Chin Yun
AU - Huang, Fu Yuan
AU - Huang, Li Min
PY - 2006/11
Y1 - 2006/11
N2 - From 2003 to 2005, we prospectively collected 118 isolates of pneumococci belonging to 7 serotypes to investigate their competence under the influence of the synthetic competence-stimulating peptides. The degree of competence of the various serotypes differed significantly. Serotype 6B had the highest competence, followed by serotypes 14, 19F, 9V, 23F, 3, and 18C. Isolates belonging to serotype 6B had greater genetic diversity than isolates belonging to serotype 3, which has high genetic clustering. Isolates belonging to serotypes 3 and 18C that were 100% sensitive to penicillin were significantly less competent than isolates belonging to serotypes 6B, 14, 19F, 9V, and 23F, which were frequently resistant to penicillin. Under the 7-valent pneumococcal conjugate vaccine program, enhanced molecular surveillance of virulent clones with higher competence to detect serotype switching will become more important.
AB - From 2003 to 2005, we prospectively collected 118 isolates of pneumococci belonging to 7 serotypes to investigate their competence under the influence of the synthetic competence-stimulating peptides. The degree of competence of the various serotypes differed significantly. Serotype 6B had the highest competence, followed by serotypes 14, 19F, 9V, 23F, 3, and 18C. Isolates belonging to serotype 6B had greater genetic diversity than isolates belonging to serotype 3, which has high genetic clustering. Isolates belonging to serotypes 3 and 18C that were 100% sensitive to penicillin were significantly less competent than isolates belonging to serotypes 6B, 14, 19F, 9V, and 23F, which were frequently resistant to penicillin. Under the 7-valent pneumococcal conjugate vaccine program, enhanced molecular surveillance of virulent clones with higher competence to detect serotype switching will become more important.
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U2 - 10.3201/eid1211.060414
DO - 10.3201/eid1211.060414
M3 - Article
C2 - 17283621
AN - SCOPUS:33750571854
SN - 1080-6040
VL - 12
SP - 1709
EP - 1714
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 11
ER -
