Serological response and persistence in schoolchildren with high baseline seropositive rate after receiving 2009 pandemic influenza A(H1N1) vaccine

Day Yu Chao; Kuang Fu Cheng; Ying Hen Hsieh; Tsai Chung Li; Trong Neng Wu; Chiu Ying Chen; Chen An Tsai; Jin Hwa Chen; Hsien Tsai Chiu; Jang Jih Lu; Mei Chi Su; Yu Hsin Liao

doi:10.1016/j.vaccine.2010.11.016

Serological response and persistence in schoolchildren with high baseline seropositive rate after receiving 2009 pandemic influenza A(H1N1) vaccine

Day Yu Chao, Kuang Fu Cheng, Ying Hen Hsieh, Tsai Chung Li, Trong Neng Wu, Chiu Ying Chen, Chen An Tsai, Jin Hwa Chen, Hsien Tsai Chiu, Jang Jih Lu, Mei Chi Su, Yu Hsin Liao

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The serological response of the current 2009 H1N1 pandemic influenza monovalent vaccine in children exhibiting high baseline seropositive rate was evaluated though a community-based household study. Seroprotection rate of >90% and seroconversion rate of >50% were observed in children one month after receiving the pandemic vaccine. Among children with low baseline antibody titer, a significant lower seroconversion rate (55%) was observed in children who received seasonal trivalent inactivated vaccine (TIV) prior to pandemic vaccine, when compared with those receiving the pandemic vaccine only (86%). Persistence of antibody against the pandemic influenza virus was observed 6 months after vaccination in >80% of children presenting seroprotective antibody levels.

Original language	English
Pages (from-to)	617-623
Number of pages	7
Journal	Vaccine
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/j.vaccine.2010.11.016
Publication status	Published - Jan 17 2011
Externally published	Yes

Keywords

2009 pH1N1
Immune response
Pandemic influenza
Schoolchildren
Serology
Vaccine

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2010.11.016

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Chao, D. Y., Cheng, K. F., Hsieh, Y. H., Li, T. C., Wu, T. N., Chen, C. Y., Tsai, C. A., Chen, J. H., Chiu, H. T., Lu, J. J., Su, M. C., & Liao, Y. H. (2011). Serological response and persistence in schoolchildren with high baseline seropositive rate after receiving 2009 pandemic influenza A(H1N1) vaccine. Vaccine, 29(4), 617-623. https://doi.org/10.1016/j.vaccine.2010.11.016

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title = "Serological response and persistence in schoolchildren with high baseline seropositive rate after receiving 2009 pandemic influenza A(H1N1) vaccine",

abstract = "The serological response of the current 2009 H1N1 pandemic influenza monovalent vaccine in children exhibiting high baseline seropositive rate was evaluated though a community-based household study. Seroprotection rate of >90% and seroconversion rate of >50% were observed in children one month after receiving the pandemic vaccine. Among children with low baseline antibody titer, a significant lower seroconversion rate (55%) was observed in children who received seasonal trivalent inactivated vaccine (TIV) prior to pandemic vaccine, when compared with those receiving the pandemic vaccine only (86%). Persistence of antibody against the pandemic influenza virus was observed 6 months after vaccination in >80% of children presenting seroprotective antibody levels.",

keywords = "2009 pH1N1, Immune response, Pandemic influenza, Schoolchildren, Serology, Vaccine",

author = "Chao, {Day Yu} and Cheng, {Kuang Fu} and Hsieh, {Ying Hen} and Li, {Tsai Chung} and Wu, {Trong Neng} and Chen, {Chiu Ying} and Tsai, {Chen An} and Chen, {Jin Hwa} and Chiu, {Hsien Tsai} and Lu, {Jang Jih} and Su, {Mei Chi} and Liao, {Yu Hsin}",

note = "Funding Information: This study was supported by National Science Council of Taiwan and China Medical University . ",

year = "2011",

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doi = "10.1016/j.vaccine.2010.11.016",

language = "English",

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AU - Cheng, Kuang Fu

AU - Hsieh, Ying Hen

AU - Li, Tsai Chung

AU - Wu, Trong Neng

AU - Chen, Chiu Ying

AU - Tsai, Chen An

AU - Chen, Jin Hwa

AU - Chiu, Hsien Tsai

AU - Lu, Jang Jih

AU - Su, Mei Chi

AU - Liao, Yu Hsin

N1 - Funding Information: This study was supported by National Science Council of Taiwan and China Medical University .

PY - 2011/1/17

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KW - 2009 pH1N1

KW - Immune response

KW - Pandemic influenza

KW - Schoolchildren

KW - Serology

KW - Vaccine

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Serological response and persistence in schoolchildren with high baseline seropositive rate after receiving 2009 pandemic influenza A(H1N1) vaccine

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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