Sensing acidosis: Nociception or sngception?

Jiann Her Lin, Chih Hsien Hung, Der Sheng Han, Shih Ting Chen, Cheng Han Lee, Wei Zen Sun, Chih Cheng Chen

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)


Background: Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli. Main body: In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia, and radicular pain. However, soreness sensation is a sign of successful analgesia for acupuncture and noxipoint therapy. Thus, the nature of acid or soreness sensation is not always nociceptive (or painful) and could be anti-nociceptive. To facilitate the investigation of the molecular and neurobiological mechanisms of soreness sensation, we propose a concept called "sngception (sng- ception)" to describe the response of the somatosensory nervous system to sense tissue acidosis and to distinguish it from nociception. "Sng" is a Taiwanese word that represents the state of soreness while at the same time imitates the natural vocalization of humans feeling sore. Conclusion: Here we propose sngception as a specific somatosensory function that transmits the acid sensation from the peripheral to the central nervous system. Sngception could partially overlap with nociception, but it could also transmit antinociception, proprioception, and pruriception.

Original languageEnglish
Article number85
JournalJournal of Biomedical Science
Issue number1
Publication statusPublished - Nov 29 2018


  • Acidosis
  • ASIC3
  • Nociception
  • Pain
  • Sngception
  • Soreness

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)


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