Self processing in the brain: A paradigmatic fMRI case study with a professional singer

Yuliya S. Zaytseva; Evgeny Gutyrchik; Yan Bao; Ernst O. Pöppel; Shi-Hui Han; Georg Franz Josef Northoff; Lorenz Welker; Thomas M. Meindl; Janusch Blautzik

doi:10.1016/j.bandc.2014.03.012

Self processing in the brain: A paradigmatic fMRI case study with a professional singer

Yuliya S. Zaytseva, Evgeny Gutyrchik, Yan Bao, Ernst O. Pöppel, Shi-Hui Han, Georg Franz Josef Northoff, Lorenz Welker, Thomas M. Meindl, Janusch Blautzik

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Understanding the mechanisms involved in perception and conception of oneself is a fundamental psychological topic with high relevance for psychiatric and neurological issues, and it is one of the great challenges in neuroscientific research. The paradigmatic single-case study presented here aimed to investigate different components of self- and other-processes and to elucidate corresponding neurobiological underpinnings. An eminent professional opera singer with profound performance experience has undergone functional magnetic resonance imaging and was exposed to excerpts of Mozart arias, sung by herself or another singer. The results indicate a distinction between self- and other conditions in cortical midline structures, differentially involved in self-related and self-referential processing. This lends further support to the assumption of cortical midline structures being involved in the neural processing of self-specific stimuli and also confirms the power of single case studies as a research tool. © 2014 Elsevier Inc.

Original language	English
Pages (from-to)	104-108
Number of pages	5
Journal	Brain and Cognition
Volume	87
Issue number	1
DOIs	https://doi.org/10.1016/j.bandc.2014.03.012
Publication status	Published - 2014
Externally published	Yes

Keywords

Cortical midline structures
Functional magnetic resonance imaging
Professional identity
Self-referential processing
Self-related processing
Temporal processing
adult
aged
anterior cingulate
article
auditory discrimination
auditory stimulation
BOLD signal
brain function
controlled study
female
functional magnetic resonance imaging
functional neuroimaging
human
human experiment
male
nerve cell network
normal human
orbital cortex
physical performance
precuneus
prefrontal cortex
priority journal
self concept
singing
superior frontal gyrus
task performance
temporal cortex
temporal gyrus
brain
brain mapping
case report
nuclear magnetic resonance imaging
physiology
Aged
Brain
Brain Mapping
Female
Humans
Magnetic Resonance Imaging
Self Concept
Singing

Access to Document

10.1016/j.bandc.2014.03.012

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922015265&partnerID=40&md5=383ca252281103f7295b88861017964b

Cite this

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title = "Self processing in the brain: A paradigmatic fMRI case study with a professional singer",

abstract = "Understanding the mechanisms involved in perception and conception of oneself is a fundamental psychological topic with high relevance for psychiatric and neurological issues, and it is one of the great challenges in neuroscientific research. The paradigmatic single-case study presented here aimed to investigate different components of self- and other-processes and to elucidate corresponding neurobiological underpinnings. An eminent professional opera singer with profound performance experience has undergone functional magnetic resonance imaging and was exposed to excerpts of Mozart arias, sung by herself or another singer. The results indicate a distinction between self- and other conditions in cortical midline structures, differentially involved in self-related and self-referential processing. This lends further support to the assumption of cortical midline structures being involved in the neural processing of self-specific stimuli and also confirms the power of single case studies as a research tool. {\textcopyright} 2014 Elsevier Inc.",

keywords = "Cortical midline structures, Functional magnetic resonance imaging, Professional identity, Self-referential processing, Self-related processing, Temporal processing, adult, aged, anterior cingulate, article, auditory discrimination, auditory stimulation, BOLD signal, brain function, controlled study, female, functional magnetic resonance imaging, functional neuroimaging, human, human experiment, male, nerve cell network, normal human, orbital cortex, physical performance, precuneus, prefrontal cortex, priority journal, self concept, singing, superior frontal gyrus, task performance, temporal cortex, temporal gyrus, brain, brain mapping, case report, nuclear magnetic resonance imaging, physiology, Aged, Brain, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Self Concept, Singing",

author = "Zaytseva, {Yuliya S.} and Evgeny Gutyrchik and Yan Bao and P{\"o}ppel, {Ernst O.} and Shi-Hui Han and Northoff, {Georg Franz Josef} and Lorenz Welker and Meindl, {Thomas M.} and Janusch Blautzik",

note = "Cited By :5 Export Date: 11 May 2016 CODEN: BRCOE Correspondence Address: P{\"o}ppel, E.; Human Science Center, Ludwig Maximilian University, Goethestr, 31, 80336 Munich, Germany; email: [email protected] References: Bao, Y., P{\"o}ppel, E., Anthropological universals and cultural specifics: Conceptual and methodological challenges in cultural neuroscience (2012) Neuroscience and Biobehavioral Reviews, 36, pp. 2143-2146; Carter, C.S., Braver, T.S., Barch, D.M., Botvinick, M.M., Noll, D., Cohen, J.D., Anterior cingulate cortex, error detection, and the online monitoring of performance (1998) Science, 280, pp. 747-749; Craig, A.D., Interoception: the sense of the physiological condition of the body (2003) Current Opinion in Neurobiology, 13, pp. 500-505; D'Argembeau, A., Collette, F., Van der Linden, M., Laureys, S., Del Fiore, G., Degueldre, C., Self-referential reflective activity and its relationship with rest: A PET study (2005) Neuroimage, 25, pp. 616-624; Decety, J., Sjoholm, H., Ryding, E., Stenberg, G., Ingvar, D.H., The cerebellum participates in mental activity (1990) Brain Research, 535, pp. 313-317; D'Esposito, M., Detre, J.A., Aguirre, G.K., Stallcup, M., Alsop, D.C., Tippet, L.J., A functional MRI study of mental image generation (1997) Neuropsychologia, 35, pp. 725-730; Farrer, C., Frey, S.H., Van Horn, J.D., Tunik, E., Turk, D., Inati, S., The angular gyrus computes action awareness representations (2008) Cerebral Cortex, 18, pp. 254-261; Flyvbjerg, B., Five misunderstandings about case study research (2006) Qualitative Enquiry, 12, pp. 219-245; Gallagher, S., Philosophical conceptions of the self: Implications for cognitive science (2000) Trends in Cognitive Sciences, 4, pp. 14-21; Grimm, S., Ernst, J., Boesiger, P., Schuepbach, D., Hell, D., Boeker, H., Increased self-focus in major depressive disorder is related to neural abnormalities in subcortical-cortical midline structures (2009) Human Brain Mapping, 30, pp. 2617-2627; Han, S., Northoff, G., Understanding the self: A cultural neuroscience approach (2009) Progress in Brain Research, 178, pp. 203-212; James, W., (1957) The principles of psychology, , Dover Publications, New York; Keenan, J.P., Wheeler, M.A., Gallup, G.G., Pascual-Leone, A., Self-recognition and the right prefrontal cortex (2000) Trends in Cognitive Sciences, 4, pp. 338-344; Kjaer, T.W., Nowak, M., Lou, H.C., Reflective self-awareness and conscious states: PET evidence for a common midline parietofrontal core (2002) Neuroimage, 17, pp. 1080-1086; Miller, E.K., Freedman, D.J., Wallis, J.D., The prefrontal cortex: Categories concepts and cognition (2002) Philosophical Transactions of the Royal Society of London. B: Biological Sciences, 357, pp. 1123-1136; Moran, J.M., Heatherton, T.F., Kelley, W.M., Modulation of cortical midline structures by implicit and explicit self-relevance evaluation (2009) Social Neuroscience, 4, pp. 197-211; Moran, J.M., Macrae, C.N., Heatherton, T.F., Wyland, C.L., Kelly, W.M., Neuroanatomical evidence for distinct cognitive and affective components of self (2006) Journal of Cognitive Neuroscience, 18, pp. 1586-1594; Northoff, G., Bermpohl, F., Cortical midline structures and the self (2004) Trends in Cognitive Sciences, 8, pp. 102-107; Northoff, G., Heinzel, A., de Greck, M., Bermpohl, F., Dobrowolny, H., Panksepp, J., Self-referential processing in our brain - A meta-analysis of imaging studies on the self (2006) NeuroImage, 31, pp. 440-457; Northoff, G., Richter, A., Gessner, M., Schlagenhauf, F., Fell, J., Baumgart, F., Differential parametric modulation of self-relatedness and emotions in different brain regions (2009) Human Brain Mapping, 30, pp. 369-382; Northoff, G., Qin, P., Nakao, T., Rest-stimulus interaction in the brain: A review (2010) Trends in Neuroscience, 33, pp. 277-284; Panksepp, J., The periconscious substrates of consciousness: Affective states and the evolutionary origins of the self (1998) Journal of Consciousness Studies, 5, pp. 566-582; P{\"o}ppel, E., Pre-semantically defined temporal windows for cognitive processing (2009) Philosophical Transactions of the Royal Society B: Biological Sciences, 364, pp. 1887-1896; P{\"o}ppel, E., Bao, Y., Three modes of knowledge as basis for intercultural cognition and communication: A theoretical perspective (2011) Culture and neural frames of cognition and communication, pp. 215-231. , Springer-Verlag, Heidelberg, S. Han, E. P{\"o}ppel (Eds.); P{\"o}ppel, E., Bao, Y., Temporal windows as bridge to objective time to subjective time (2014) Subjective time: the philosophy, psychology, and neuroscience of temporality, pp. 241-261. , MIT Press, Cambridge, D. Lloyd, V. Arstila (Eds.); P{\"o}ppel, E., Perceptual identity and personal self: Neurobiological reflections (2010) Personality from biological, cognitive, and social perspectives, pp. 75-82. , Eliot Werner Publications, Clinton Corners, New York, T. Maruszewski, M. Fajkowska, M. Eysenck (Eds.); Pribram, K.H., The self as me and I (1999) Consciousness and Cognition, 8, pp. 385-386; Qin, P., Di, H., Liu, Y., Yu, S., Gong, Q., Duncan, N., Anterior cingulate activity and the self in disorders of consciousness (2010) Human Brain Mapping, 31, pp. 1993-2002; Qin, P., Northoff, G., How is our self related to midline regions and the default-mode network? (2011) Neuroimage, 57, pp. 1221-1233; Schneider, F., Bermpohl, F., Heinzel, A., Rotte, M., Walter, M., Tempelmann, C., The resting brain and our self: Self-relatedness modulates resting state neural activity in cortical midline structures (2008) Neuroscience, 157, pp. 120-131; Stich, S.P., Warfield, T.A., (1994) Mental representation: A reader, , Blackwell, Oxford; Strata, P., Scelfo, B., Sacchetti, B., Involvement of cerebellum in emotional behavior (2011) Physiological Research, 60, pp. 39-48; Strawson, G., The phenomenology and ontology of the self (2002) Exploring the Self: Philosophical and psychopathological perspectives on self-experience, pp. 39-54. , John Benjamins, Amsterdam, D. Zahavi (Ed.); Svoboda, E., McKinnon, M.C., Levine, B., The functional neuroanatomy of autobiographical memory (2006) Neuropsychologia, 44, pp. 2189-2208; Tyll, S., Budinger, E., Noesselt, T., Thalamic influences on multisensory integration (2011) Communicative and Integrative Biology, 4, pp. 378-381; Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Automated anatomical labelling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain (2002) Neuroimage, 15, pp. 273-289; Vogeley, K., May, M., Ritzl, A., Falkai, P., Zilles, K., Fink, G.R., Neural correlates of first-person perspective (2004) Journal of Cognitive Neuroscience, 16, pp. 817-827; Whitfield-Gabrieli, S., Moran, J., Nieto-Casta{\~n}{\'o}n, A., Triantafyllou, C., Saxe, R., Gabrieli, J.D.E., Associations and dissociations between default and self-reference networks in the human brain (2011) Neuroimage, 55, pp. 225-232; Zahavi, D., First-personal self-reference and the self-as-subject (2007) Consciousness and Cognition, 16, pp. 600-603",

year = "2014",

doi = "10.1016/j.bandc.2014.03.012",

language = "English",

volume = "87",

pages = "104--108",

journal = "Brain and Cognition",

issn = "0278-2626",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Self processing in the brain: A paradigmatic fMRI case study with a professional singer

AU - Zaytseva, Yuliya S.

AU - Gutyrchik, Evgeny

AU - Bao, Yan

AU - Pöppel, Ernst O.

AU - Han, Shi-Hui

AU - Northoff, Georg Franz Josef

AU - Welker, Lorenz

AU - Meindl, Thomas M.

AU - Blautzik, Janusch

N1 - Cited By :5 Export Date: 11 May 2016 CODEN: BRCOE Correspondence Address: Pöppel, E.; Human Science Center, Ludwig Maximilian University, Goethestr, 31, 80336 Munich, Germany; email: [email protected] References: Bao, Y., Pöppel, E., Anthropological universals and cultural specifics: Conceptual and methodological challenges in cultural neuroscience (2012) Neuroscience and Biobehavioral Reviews, 36, pp. 2143-2146; Carter, C.S., Braver, T.S., Barch, D.M., Botvinick, M.M., Noll, D., Cohen, J.D., Anterior cingulate cortex, error detection, and the online monitoring of performance (1998) Science, 280, pp. 747-749; Craig, A.D., Interoception: the sense of the physiological condition of the body (2003) Current Opinion in Neurobiology, 13, pp. 500-505; D'Argembeau, A., Collette, F., Van der Linden, M., Laureys, S., Del Fiore, G., Degueldre, C., Self-referential reflective activity and its relationship with rest: A PET study (2005) Neuroimage, 25, pp. 616-624; Decety, J., Sjoholm, H., Ryding, E., Stenberg, G., Ingvar, D.H., The cerebellum participates in mental activity (1990) Brain Research, 535, pp. 313-317; D'Esposito, M., Detre, J.A., Aguirre, G.K., Stallcup, M., Alsop, D.C., Tippet, L.J., A functional MRI study of mental image generation (1997) Neuropsychologia, 35, pp. 725-730; Farrer, C., Frey, S.H., Van Horn, J.D., Tunik, E., Turk, D., Inati, S., The angular gyrus computes action awareness representations (2008) Cerebral Cortex, 18, pp. 254-261; Flyvbjerg, B., Five misunderstandings about case study research (2006) Qualitative Enquiry, 12, pp. 219-245; Gallagher, S., Philosophical conceptions of the self: Implications for cognitive science (2000) Trends in Cognitive Sciences, 4, pp. 14-21; Grimm, S., Ernst, J., Boesiger, P., Schuepbach, D., Hell, D., Boeker, H., Increased self-focus in major depressive disorder is related to neural abnormalities in subcortical-cortical midline structures (2009) Human Brain Mapping, 30, pp. 2617-2627; Han, S., Northoff, G., Understanding the self: A cultural neuroscience approach (2009) Progress in Brain Research, 178, pp. 203-212; James, W., (1957) The principles of psychology, , Dover Publications, New York; Keenan, J.P., Wheeler, M.A., Gallup, G.G., Pascual-Leone, A., Self-recognition and the right prefrontal cortex (2000) Trends in Cognitive Sciences, 4, pp. 338-344; Kjaer, T.W., Nowak, M., Lou, H.C., Reflective self-awareness and conscious states: PET evidence for a common midline parietofrontal core (2002) Neuroimage, 17, pp. 1080-1086; Miller, E.K., Freedman, D.J., Wallis, J.D., The prefrontal cortex: Categories concepts and cognition (2002) Philosophical Transactions of the Royal Society of London. B: Biological Sciences, 357, pp. 1123-1136; Moran, J.M., Heatherton, T.F., Kelley, W.M., Modulation of cortical midline structures by implicit and explicit self-relevance evaluation (2009) Social Neuroscience, 4, pp. 197-211; Moran, J.M., Macrae, C.N., Heatherton, T.F., Wyland, C.L., Kelly, W.M., Neuroanatomical evidence for distinct cognitive and affective components of self (2006) Journal of Cognitive Neuroscience, 18, pp. 1586-1594; Northoff, G., Bermpohl, F., Cortical midline structures and the self (2004) Trends in Cognitive Sciences, 8, pp. 102-107; Northoff, G., Heinzel, A., de Greck, M., Bermpohl, F., Dobrowolny, H., Panksepp, J., Self-referential processing in our brain - A meta-analysis of imaging studies on the self (2006) NeuroImage, 31, pp. 440-457; Northoff, G., Richter, A., Gessner, M., Schlagenhauf, F., Fell, J., Baumgart, F., Differential parametric modulation of self-relatedness and emotions in different brain regions (2009) Human Brain Mapping, 30, pp. 369-382; Northoff, G., Qin, P., Nakao, T., Rest-stimulus interaction in the brain: A review (2010) Trends in Neuroscience, 33, pp. 277-284; Panksepp, J., The periconscious substrates of consciousness: Affective states and the evolutionary origins of the self (1998) Journal of Consciousness Studies, 5, pp. 566-582; Pöppel, E., Pre-semantically defined temporal windows for cognitive processing (2009) Philosophical Transactions of the Royal Society B: Biological Sciences, 364, pp. 1887-1896; Pöppel, E., Bao, Y., Three modes of knowledge as basis for intercultural cognition and communication: A theoretical perspective (2011) Culture and neural frames of cognition and communication, pp. 215-231. , Springer-Verlag, Heidelberg, S. Han, E. Pöppel (Eds.); Pöppel, E., Bao, Y., Temporal windows as bridge to objective time to subjective time (2014) Subjective time: the philosophy, psychology, and neuroscience of temporality, pp. 241-261. , MIT Press, Cambridge, D. Lloyd, V. Arstila (Eds.); Pöppel, E., Perceptual identity and personal self: Neurobiological reflections (2010) Personality from biological, cognitive, and social perspectives, pp. 75-82. , Eliot Werner Publications, Clinton Corners, New York, T. Maruszewski, M. Fajkowska, M. Eysenck (Eds.); Pribram, K.H., The self as me and I (1999) Consciousness and Cognition, 8, pp. 385-386; Qin, P., Di, H., Liu, Y., Yu, S., Gong, Q., Duncan, N., Anterior cingulate activity and the self in disorders of consciousness (2010) Human Brain Mapping, 31, pp. 1993-2002; Qin, P., Northoff, G., How is our self related to midline regions and the default-mode network? (2011) Neuroimage, 57, pp. 1221-1233; Schneider, F., Bermpohl, F., Heinzel, A., Rotte, M., Walter, M., Tempelmann, C., The resting brain and our self: Self-relatedness modulates resting state neural activity in cortical midline structures (2008) Neuroscience, 157, pp. 120-131; Stich, S.P., Warfield, T.A., (1994) Mental representation: A reader, , Blackwell, Oxford; Strata, P., Scelfo, B., Sacchetti, B., Involvement of cerebellum in emotional behavior (2011) Physiological Research, 60, pp. 39-48; Strawson, G., The phenomenology and ontology of the self (2002) Exploring the Self: Philosophical and psychopathological perspectives on self-experience, pp. 39-54. , John Benjamins, Amsterdam, D. Zahavi (Ed.); Svoboda, E., McKinnon, M.C., Levine, B., The functional neuroanatomy of autobiographical memory (2006) Neuropsychologia, 44, pp. 2189-2208; Tyll, S., Budinger, E., Noesselt, T., Thalamic influences on multisensory integration (2011) Communicative and Integrative Biology, 4, pp. 378-381; Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Automated anatomical labelling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain (2002) Neuroimage, 15, pp. 273-289; Vogeley, K., May, M., Ritzl, A., Falkai, P., Zilles, K., Fink, G.R., Neural correlates of first-person perspective (2004) Journal of Cognitive Neuroscience, 16, pp. 817-827; Whitfield-Gabrieli, S., Moran, J., Nieto-Castañón, A., Triantafyllou, C., Saxe, R., Gabrieli, J.D.E., Associations and dissociations between default and self-reference networks in the human brain (2011) Neuroimage, 55, pp. 225-232; Zahavi, D., First-personal self-reference and the self-as-subject (2007) Consciousness and Cognition, 16, pp. 600-603

PY - 2014

Y1 - 2014

N2 - Understanding the mechanisms involved in perception and conception of oneself is a fundamental psychological topic with high relevance for psychiatric and neurological issues, and it is one of the great challenges in neuroscientific research. The paradigmatic single-case study presented here aimed to investigate different components of self- and other-processes and to elucidate corresponding neurobiological underpinnings. An eminent professional opera singer with profound performance experience has undergone functional magnetic resonance imaging and was exposed to excerpts of Mozart arias, sung by herself or another singer. The results indicate a distinction between self- and other conditions in cortical midline structures, differentially involved in self-related and self-referential processing. This lends further support to the assumption of cortical midline structures being involved in the neural processing of self-specific stimuli and also confirms the power of single case studies as a research tool. © 2014 Elsevier Inc.

AB - Understanding the mechanisms involved in perception and conception of oneself is a fundamental psychological topic with high relevance for psychiatric and neurological issues, and it is one of the great challenges in neuroscientific research. The paradigmatic single-case study presented here aimed to investigate different components of self- and other-processes and to elucidate corresponding neurobiological underpinnings. An eminent professional opera singer with profound performance experience has undergone functional magnetic resonance imaging and was exposed to excerpts of Mozart arias, sung by herself or another singer. The results indicate a distinction between self- and other conditions in cortical midline structures, differentially involved in self-related and self-referential processing. This lends further support to the assumption of cortical midline structures being involved in the neural processing of self-specific stimuli and also confirms the power of single case studies as a research tool. © 2014 Elsevier Inc.

KW - Cortical midline structures

KW - Functional magnetic resonance imaging

KW - Professional identity

KW - Self-referential processing

KW - Self-related processing

KW - Temporal processing

KW - adult

KW - aged

KW - anterior cingulate

KW - article

KW - auditory discrimination

KW - auditory stimulation

KW - BOLD signal

KW - brain function

KW - controlled study

KW - female

KW - functional magnetic resonance imaging

KW - functional neuroimaging

KW - human

KW - human experiment

KW - male

KW - nerve cell network

KW - normal human

KW - orbital cortex

KW - physical performance

KW - precuneus

KW - prefrontal cortex

KW - priority journal

KW - self concept

KW - singing

KW - superior frontal gyrus

KW - task performance

KW - temporal cortex

KW - temporal gyrus

KW - brain

KW - brain mapping

KW - case report

KW - nuclear magnetic resonance imaging

KW - physiology

KW - Aged

KW - Brain

KW - Brain Mapping

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Self Concept

KW - Singing

U2 - 10.1016/j.bandc.2014.03.012

DO - 10.1016/j.bandc.2014.03.012

M3 - Article

C2 - 24732954

SN - 0278-2626

VL - 87

SP - 104

EP - 108

JO - Brain and Cognition

JF - Brain and Cognition

IS - 1

ER -

Self processing in the brain: A paradigmatic fMRI case study with a professional singer

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Keywords

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