Selective laser sintering of a hydroxyapatite-silica scaffold on cultured MG63 osteoblasts in vitro

Fwu Hsing Liu; Yung Kang Shen; Jeou Long Lee

doi:10.1007/s12541-012-0056-9

Selective laser sintering of a hydroxyapatite-silica scaffold on cultured MG63 osteoblasts in vitro

Fwu Hsing Liu, Yung Kang Shen, Jeou Long Lee

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

This study forms hydroxyapatite-silica ceramic structure, which can generate interconnected porous 3D models suitable as bone scaffold, using a novel selective laser sintering (SLS) technique. Hydroxyapatite (HA) powder and a silica sol are first mixed into slurries. After processing by SLS, the HA particles are embedded in the gelled silica matrix to form green parts. The processed parts are analyzed by scanning electron microscopy (SEM). The number of cells attached on this scaffold surface is obtained by the in vitro cultured cells test. The higher number of viable cells are obtained when the sintering temperature of the scaffold was 1200°C at day 4 of cell culturing. The proposed technology can be applied to generate a bone scaffold model of porous bio-ceramics for biomedicine.

Original language	English
Pages (from-to)	439-444
Number of pages	6
Journal	International Journal of Precision Engineering and Manufacturing
Volume	13
Issue number	3
DOIs	https://doi.org/10.1007/s12541-012-0056-9
Publication status	Published - Mar 2012

Keywords

Ceramics
Powder processing
Scanning electron microscopy (SEM)
Sol-gel methods

ASJC Scopus subject areas

Mechanical Engineering
Industrial and Manufacturing Engineering
Electrical and Electronic Engineering

Access to Document

10.1007/s12541-012-0056-9

Cite this

@article{f1c32a6d69064052b3c53c35319b7f4a,

title = "Selective laser sintering of a hydroxyapatite-silica scaffold on cultured MG63 osteoblasts in vitro",

abstract = "This study forms hydroxyapatite-silica ceramic structure, which can generate interconnected porous 3D models suitable as bone scaffold, using a novel selective laser sintering (SLS) technique. Hydroxyapatite (HA) powder and a silica sol are first mixed into slurries. After processing by SLS, the HA particles are embedded in the gelled silica matrix to form green parts. The processed parts are analyzed by scanning electron microscopy (SEM). The number of cells attached on this scaffold surface is obtained by the in vitro cultured cells test. The higher number of viable cells are obtained when the sintering temperature of the scaffold was 1200°C at day 4 of cell culturing. The proposed technology can be applied to generate a bone scaffold model of porous bio-ceramics for biomedicine.",

keywords = "Ceramics, Powder processing, Scanning electron microscopy (SEM), Sol-gel methods",

author = "Liu, {Fwu Hsing} and Shen, {Yung Kang} and Lee, {Jeou Long}",

note = "Funding Information: This work was supported by the National Science Council of the Republic of China, Taiwan, under Contract Nos. NSC 99-2221-E-262-003 and NSC 98-2221-E-038-001. We also gratefully acknowledge financial support from the Ministry of Education of the Republic of China, Taiwan, under Contract No. 99M-88-067.",

year = "2012",

month = mar,

doi = "10.1007/s12541-012-0056-9",

language = "English",

volume = "13",

pages = "439--444",

journal = "International Journal of Precision Engineering and Manufacturing",

issn = "1229-8557",

publisher = "Korean Society of Precision Engineering",

number = "3",

}

TY - JOUR

T1 - Selective laser sintering of a hydroxyapatite-silica scaffold on cultured MG63 osteoblasts in vitro

AU - Liu, Fwu Hsing

AU - Shen, Yung Kang

AU - Lee, Jeou Long

N1 - Funding Information: This work was supported by the National Science Council of the Republic of China, Taiwan, under Contract Nos. NSC 99-2221-E-262-003 and NSC 98-2221-E-038-001. We also gratefully acknowledge financial support from the Ministry of Education of the Republic of China, Taiwan, under Contract No. 99M-88-067.

PY - 2012/3

Y1 - 2012/3

N2 - This study forms hydroxyapatite-silica ceramic structure, which can generate interconnected porous 3D models suitable as bone scaffold, using a novel selective laser sintering (SLS) technique. Hydroxyapatite (HA) powder and a silica sol are first mixed into slurries. After processing by SLS, the HA particles are embedded in the gelled silica matrix to form green parts. The processed parts are analyzed by scanning electron microscopy (SEM). The number of cells attached on this scaffold surface is obtained by the in vitro cultured cells test. The higher number of viable cells are obtained when the sintering temperature of the scaffold was 1200°C at day 4 of cell culturing. The proposed technology can be applied to generate a bone scaffold model of porous bio-ceramics for biomedicine.

AB - This study forms hydroxyapatite-silica ceramic structure, which can generate interconnected porous 3D models suitable as bone scaffold, using a novel selective laser sintering (SLS) technique. Hydroxyapatite (HA) powder and a silica sol are first mixed into slurries. After processing by SLS, the HA particles are embedded in the gelled silica matrix to form green parts. The processed parts are analyzed by scanning electron microscopy (SEM). The number of cells attached on this scaffold surface is obtained by the in vitro cultured cells test. The higher number of viable cells are obtained when the sintering temperature of the scaffold was 1200°C at day 4 of cell culturing. The proposed technology can be applied to generate a bone scaffold model of porous bio-ceramics for biomedicine.

KW - Ceramics

KW - Powder processing

KW - Scanning electron microscopy (SEM)

KW - Sol-gel methods

UR - http://www.scopus.com/inward/record.url?scp=84863387936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863387936&partnerID=8YFLogxK

U2 - 10.1007/s12541-012-0056-9

DO - 10.1007/s12541-012-0056-9

M3 - Article

AN - SCOPUS:84863387936

SN - 1229-8557

VL - 13

SP - 439

EP - 444

JO - International Journal of Precision Engineering and Manufacturing

JF - International Journal of Precision Engineering and Manufacturing

IS - 3

ER -

Selective laser sintering of a hydroxyapatite-silica scaffold on cultured MG63 osteoblasts in vitro

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this