Seizure after reversal of benzodiazepine treatment with flumazenil: A report of two cases

K. O. Ng; G. J. Tang; S. S. Hseu; C. H. Hsing; T. Y. Lee

Seizure after reversal of benzodiazepine treatment with flumazenil: A report of two cases

K. O. Ng, G. J. Tang, S. S. Hseu, C. H. Hsing, T. Y. Lee

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Abstract

Two patients developed seizure immediately after flumazenil administration that aimed to reverse the prolonged sedative effect of diazepam. The use of benzodiazepine for sedation in ICU may mask valuable information relevant to an ongoing pathological change. The seizure in our patients seemed most likely to result from septic ence phalopathy which was unmasked by flumazenil. However, flumazenil has the potential to provoke seizure and should be used with caution.

Original language	English
Pages (from-to)	383-387
Number of pages	5
Journal	Chinese Medical Journal (Taipei)
Volume	53
Issue number	6
Publication status	Published - 1994
Externally published	Yes

Keywords

anesthesia
flumazenil
seizure

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Seizure after reversal of benzodiazepine treatment with flumazenil: A report of two cases",

abstract = "Two patients developed seizure immediately after flumazenil administration that aimed to reverse the prolonged sedative effect of diazepam. The use of benzodiazepine for sedation in ICU may mask valuable information relevant to an ongoing pathological change. The seizure in our patients seemed most likely to result from septic ence phalopathy which was unmasked by flumazenil. However, flumazenil has the potential to provoke seizure and should be used with caution.",

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year = "1994",

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AU - Hsing, C. H.

AU - Lee, T. Y.

PY - 1994

Y1 - 1994

N2 - Two patients developed seizure immediately after flumazenil administration that aimed to reverse the prolonged sedative effect of diazepam. The use of benzodiazepine for sedation in ICU may mask valuable information relevant to an ongoing pathological change. The seizure in our patients seemed most likely to result from septic ence phalopathy which was unmasked by flumazenil. However, flumazenil has the potential to provoke seizure and should be used with caution.

AB - Two patients developed seizure immediately after flumazenil administration that aimed to reverse the prolonged sedative effect of diazepam. The use of benzodiazepine for sedation in ICU may mask valuable information relevant to an ongoing pathological change. The seizure in our patients seemed most likely to result from septic ence phalopathy which was unmasked by flumazenil. However, flumazenil has the potential to provoke seizure and should be used with caution.

KW - anesthesia

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KW - seizure

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Seizure after reversal of benzodiazepine treatment with flumazenil: A report of two cases

Abstract

Keywords

ASJC Scopus subject areas

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