Segmentation of diffusion-weighted brain images using expectation maximization algorithm initialized by hierarchical clustering.

Chia-Feng Lu, Po-Shan Wang, Yen-Chun Chou, Hsiao-Chien Li, Bing-Wen Soong, Yu-Te Wu

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Tissue segmentation based on diffusion-weighted images (DWI) provides complementary information of tissue contrast to the structural MRI for facilitating the tissue segmentation. In the previous literatures, DWI-based brain tissue segmentation was carried out using the parametric images, such as fractional anisotropy (FA) and apparent diffusion coefficient (ADC). However, the information of directions of neural fibers was very limited in the parametric images. To fully utilize the directional information, we propose a novel method to perform tissue segmentation directly on the DWI raw image data. Specifically, a hierarchical clustering (HC) technique was first applied on the down-sampled data to initialize the model parameters for each tissue cluster followed by automatic segmentation using the expectation maximization (EM) algorithm. The whole brain DWI raw data of five normal subjects were analyzed. The results demonstrated that HC-EM is effective in multi-tissue classification on DWI raw data.
Original languageEnglish
Pages (from-to)5502-5505
Number of pages4
JournalConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
Publication statusPublished - 2008
Externally publishedYes


  • aged
  • algorithm
  • article
  • artificial intelligence
  • automated pattern recognition
  • brain
  • cluster analysis
  • computer assisted diagnosis
  • diffusion weighted imaging
  • female
  • histology
  • human
  • image enhancement
  • male
  • methodology
  • middle aged
  • reproducibility
  • sensitivity and specificity
  • statistical model
  • three dimensional imaging
  • very elderly
  • Aged
  • Aged, 80 and over
  • Algorithms
  • Artificial Intelligence
  • Brain
  • Cluster Analysis
  • Diffusion Magnetic Resonance Imaging
  • Female
  • Humans
  • Image Enhancement
  • Image Interpretation, Computer-Assisted
  • Imaging, Three-Dimensional
  • Likelihood Functions
  • Male
  • Middle Aged
  • Pattern Recognition, Automated
  • Reproducibility of Results
  • Sensitivity and Specificity


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