Abstract
Bioassay-guided fractionation of stems of Engelhardia roxburghiana led to isolation of: four diarylheptanoids, engelheptanoxides A-D (1-4); two cyclic diarylheptanoids, engelhardiols A (5) and B (6); one naphthoquinone dimer, engelharquinonol (7); and one 1-tetralone, (4S)-4,6-dihydroxy-1-tetralone (8), along with 24 known compounds (9-32). The structures of 1-8 were by spectroscopic analysis. Compounds 5, 6, 13, 22, and 23 showed antitubercular activity against Mycobacterium tuberculosis H37Rv with MIC values of 72.7, 62.1, 9.1, 15.3, and 70.1 μM, respectively.
Original language | English |
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Pages (from-to) | 118-127 |
Number of pages | 10 |
Journal | Phytochemistry |
Volume | 82 |
DOIs | |
Publication status | Published - Oct 2012 |
Externally published | Yes |
Keywords
- Antitubercular activity
- Diarylheptanoid
- Engelhardia roxburghiana
- Juglandaceae
- Naphthoquinone dimer
- Stem
- Tetralone
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Plant Science
- Horticulture