Secondary metabolites from the stems of Engelhardia roxburghiana and their antitubercular activities

Ho Chen Wu; Ming Jen Cheng; Chien Fang Peng; Shyh Chyun Yang; Hsun Shuo Chang; Chu Hung Lin; Chyi Jia Wang; Ih Sheng Chen

doi:10.1016/j.phytochem.2012.06.014

Secondary metabolites from the stems of Engelhardia roxburghiana and their antitubercular activities

Ho Chen Wu, Ming Jen Cheng, Chien Fang Peng, Shyh Chyun Yang, Hsun Shuo Chang, Chu Hung Lin, Chyi Jia Wang, Ih Sheng Chen

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Bioassay-guided fractionation of stems of Engelhardia roxburghiana led to isolation of: four diarylheptanoids, engelheptanoxides A-D (1-4); two cyclic diarylheptanoids, engelhardiols A (5) and B (6); one naphthoquinone dimer, engelharquinonol (7); and one 1-tetralone, (4S)-4,6-dihydroxy-1-tetralone (8), along with 24 known compounds (9-32). The structures of 1-8 were by spectroscopic analysis. Compounds 5, 6, 13, 22, and 23 showed antitubercular activity against Mycobacterium tuberculosis H₃₇Rv with MIC values of 72.7, 62.1, 9.1, 15.3, and 70.1 μM, respectively.

Original language	English
Pages (from-to)	118-127
Number of pages	10
Journal	Phytochemistry
Volume	82
DOIs	https://doi.org/10.1016/j.phytochem.2012.06.014
Publication status	Published - Oct 2012
Externally published	Yes

Keywords

Antitubercular activity
Diarylheptanoid
Engelhardia roxburghiana
Juglandaceae
Naphthoquinone dimer
Stem
Tetralone

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytochem.2012.06.014

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title = "Secondary metabolites from the stems of Engelhardia roxburghiana and their antitubercular activities",

abstract = "Bioassay-guided fractionation of stems of Engelhardia roxburghiana led to isolation of: four diarylheptanoids, engelheptanoxides A-D (1-4); two cyclic diarylheptanoids, engelhardiols A (5) and B (6); one naphthoquinone dimer, engelharquinonol (7); and one 1-tetralone, (4S)-4,6-dihydroxy-1-tetralone (8), along with 24 known compounds (9-32). The structures of 1-8 were by spectroscopic analysis. Compounds 5, 6, 13, 22, and 23 showed antitubercular activity against Mycobacterium tuberculosis H37Rv with MIC values of 72.7, 62.1, 9.1, 15.3, and 70.1 μM, respectively.",

keywords = "Antitubercular activity, Diarylheptanoid, Engelhardia roxburghiana, Juglandaceae, Naphthoquinone dimer, Stem, Tetralone",

author = "Wu, {Ho Chen} and Cheng, {Ming Jen} and Peng, {Chien Fang} and Yang, {Shyh Chyun} and Chang, {Hsun Shuo} and Lin, {Chu Hung} and Wang, {Chyi Jia} and Chen, {Ih Sheng}",

note = "Funding Information: This research was kindly supported by the National Science Council (NSC, Taiwan) and the Kaohsiung Medical University Research Foundation (KMUER013). ",

year = "2012",

month = oct,

doi = "10.1016/j.phytochem.2012.06.014",

language = "English",

volume = "82",

pages = "118--127",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Secondary metabolites from the stems of Engelhardia roxburghiana and their antitubercular activities

AU - Wu, Ho Chen

AU - Cheng, Ming Jen

AU - Peng, Chien Fang

AU - Yang, Shyh Chyun

AU - Chang, Hsun Shuo

AU - Lin, Chu Hung

AU - Wang, Chyi Jia

AU - Chen, Ih Sheng

N1 - Funding Information: This research was kindly supported by the National Science Council (NSC, Taiwan) and the Kaohsiung Medical University Research Foundation (KMUER013).

PY - 2012/10

Y1 - 2012/10

N2 - Bioassay-guided fractionation of stems of Engelhardia roxburghiana led to isolation of: four diarylheptanoids, engelheptanoxides A-D (1-4); two cyclic diarylheptanoids, engelhardiols A (5) and B (6); one naphthoquinone dimer, engelharquinonol (7); and one 1-tetralone, (4S)-4,6-dihydroxy-1-tetralone (8), along with 24 known compounds (9-32). The structures of 1-8 were by spectroscopic analysis. Compounds 5, 6, 13, 22, and 23 showed antitubercular activity against Mycobacterium tuberculosis H37Rv with MIC values of 72.7, 62.1, 9.1, 15.3, and 70.1 μM, respectively.

AB - Bioassay-guided fractionation of stems of Engelhardia roxburghiana led to isolation of: four diarylheptanoids, engelheptanoxides A-D (1-4); two cyclic diarylheptanoids, engelhardiols A (5) and B (6); one naphthoquinone dimer, engelharquinonol (7); and one 1-tetralone, (4S)-4,6-dihydroxy-1-tetralone (8), along with 24 known compounds (9-32). The structures of 1-8 were by spectroscopic analysis. Compounds 5, 6, 13, 22, and 23 showed antitubercular activity against Mycobacterium tuberculosis H37Rv with MIC values of 72.7, 62.1, 9.1, 15.3, and 70.1 μM, respectively.

KW - Antitubercular activity

KW - Diarylheptanoid

KW - Engelhardia roxburghiana

KW - Juglandaceae

KW - Naphthoquinone dimer

KW - Stem

KW - Tetralone

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DO - 10.1016/j.phytochem.2012.06.014

M3 - Article

C2 - 22818359

AN - SCOPUS:84865261494

SN - 0031-9422

VL - 82

SP - 118

EP - 127

JO - Phytochemistry

JF - Phytochemistry

ER -

Secondary metabolites from the stems of Engelhardia roxburghiana and their antitubercular activities

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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