Second transplantation from HLA 2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation

Takayuki Tanaka; Hiroshi Matsubara; Souichi Adachi; Hsi Chang; Hisanori Fujino; Yuri Higashi; Takahiro Yasumi; Michihiro Kobayashi; Ken Ichiro Watanabe; Munehisa Takahashi; Yoshiro Kobayashi; Etsuko Maruya; Hiroh Saji; Tatsutoshi Nakahata

doi:10.1532/IJH97.04063

Second transplantation from HLA 2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation

Takayuki Tanaka
, Hiroshi Matsubara
, Souichi Adachi
, Hsi Chang
, Hisanori Fujino
, Yuri Higashi
, Takahiro Yasumi
, Michihiro Kobayashi
, Ken Ichiro Watanabe
, Munehisa Takahashi
, Yoshiro Kobayashi
, Etsuko Maruya
, Hiroh Saji
, Tatsutoshi Nakahata

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

A 7-year-old girl with acute myelogenous leukemia with multilineage dysplasia received unrelated cord blood transplantation but developed hemophagocytic syndrome (HPS) after sepsis with methicillin-resistant coagulase-negative staphylococci before engraftment. Bone marrow aspiration on day 20 revealed a markedly increased number of activated macrophages showing hemophagocytosis. The presence of donor-type chimera in the bone marrow was confirmed at that time. We therefore quickly started immunosuppressive and antibacterial treatment. Although her condition gradually improved, the patient suffered graft failure due to HPS. She received peripheral blood stem cell transplantation from her HLA 2-loci-mismatched mother on day 54 and continued in complete remission 12 months after the second transplantation. The results in this case suggested that because of fetomaternal microchimerism it may be useful to select an HLA-haploidentical mother as a backup donor for stem cell transplantation.

Original language	English
Pages (from-to)	467-469
Number of pages	3
Journal	International Journal of Hematology
Volume	80
Issue number	5
DOIs	https://doi.org/10.1532/IJH97.04063
Publication status	Published - Dec 2004
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Fetomaternal
Hemophagocytosis
Second transplantation
Sepsis

ASJC Scopus subject areas

Hematology

Access to Document

10.1532/IJH97.04063

Cite this

Tanaka, T., Matsubara, H., Adachi, S., Chang, H., Fujino, H., Higashi, Y., Yasumi, T., Kobayashi, M., Watanabe, K. I., Takahashi, M., Kobayashi, Y., Maruya, E., Saji, H., & Nakahata, T. (2004). Second transplantation from HLA 2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation. International Journal of Hematology, 80(5), 467-469. https://doi.org/10.1532/IJH97.04063

Tanaka, T, Matsubara, H, Adachi, S, Chang, H, Fujino, H, Higashi, Y, Yasumi, T, Kobayashi, M, Watanabe, KI, Takahashi, M, Kobayashi, Y, Maruya, E, Saji, H & Nakahata, T 2004, 'Second transplantation from HLA 2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation', International Journal of Hematology, vol. 80, no. 5, pp. 467-469. https://doi.org/10.1532/IJH97.04063

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title = "Second transplantation from HLA 2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation",

abstract = "A 7-year-old girl with acute myelogenous leukemia with multilineage dysplasia received unrelated cord blood transplantation but developed hemophagocytic syndrome (HPS) after sepsis with methicillin-resistant coagulase-negative staphylococci before engraftment. Bone marrow aspiration on day 20 revealed a markedly increased number of activated macrophages showing hemophagocytosis. The presence of donor-type chimera in the bone marrow was confirmed at that time. We therefore quickly started immunosuppressive and antibacterial treatment. Although her condition gradually improved, the patient suffered graft failure due to HPS. She received peripheral blood stem cell transplantation from her HLA 2-loci-mismatched mother on day 54 and continued in complete remission 12 months after the second transplantation. The results in this case suggested that because of fetomaternal microchimerism it may be useful to select an HLA-haploidentical mother as a backup donor for stem cell transplantation.",

keywords = "Fetomaternal, Hemophagocytosis, Second transplantation, Sepsis",

author = "Takayuki Tanaka and Hiroshi Matsubara and Souichi Adachi and Hsi Chang and Hisanori Fujino and Yuri Higashi and Takahiro Yasumi and Michihiro Kobayashi and Watanabe, \{Ken Ichiro\} and Munehisa Takahashi and Yoshiro Kobayashi and Etsuko Maruya and Hiroh Saji and Tatsutoshi Nakahata",

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doi = "10.1532/IJH97.04063",

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AU - Tanaka, Takayuki

AU - Matsubara, Hiroshi

AU - Adachi, Souichi

AU - Chang, Hsi

AU - Fujino, Hisanori

AU - Higashi, Yuri

AU - Yasumi, Takahiro

AU - Kobayashi, Michihiro

AU - Watanabe, Ken Ichiro

AU - Takahashi, Munehisa

AU - Kobayashi, Yoshiro

AU - Maruya, Etsuko

AU - Saji, Hiroh

AU - Nakahata, Tatsutoshi

PY - 2004/12

Y1 - 2004/12

N2 - A 7-year-old girl with acute myelogenous leukemia with multilineage dysplasia received unrelated cord blood transplantation but developed hemophagocytic syndrome (HPS) after sepsis with methicillin-resistant coagulase-negative staphylococci before engraftment. Bone marrow aspiration on day 20 revealed a markedly increased number of activated macrophages showing hemophagocytosis. The presence of donor-type chimera in the bone marrow was confirmed at that time. We therefore quickly started immunosuppressive and antibacterial treatment. Although her condition gradually improved, the patient suffered graft failure due to HPS. She received peripheral blood stem cell transplantation from her HLA 2-loci-mismatched mother on day 54 and continued in complete remission 12 months after the second transplantation. The results in this case suggested that because of fetomaternal microchimerism it may be useful to select an HLA-haploidentical mother as a backup donor for stem cell transplantation.

AB - A 7-year-old girl with acute myelogenous leukemia with multilineage dysplasia received unrelated cord blood transplantation but developed hemophagocytic syndrome (HPS) after sepsis with methicillin-resistant coagulase-negative staphylococci before engraftment. Bone marrow aspiration on day 20 revealed a markedly increased number of activated macrophages showing hemophagocytosis. The presence of donor-type chimera in the bone marrow was confirmed at that time. We therefore quickly started immunosuppressive and antibacterial treatment. Although her condition gradually improved, the patient suffered graft failure due to HPS. She received peripheral blood stem cell transplantation from her HLA 2-loci-mismatched mother on day 54 and continued in complete remission 12 months after the second transplantation. The results in this case suggested that because of fetomaternal microchimerism it may be useful to select an HLA-haploidentical mother as a backup donor for stem cell transplantation.

KW - Fetomaternal

KW - Hemophagocytosis

KW - Second transplantation

KW - Sepsis

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AN - SCOPUS:19944426985

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EP - 469

JO - International Journal of Hematology

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Second transplantation from HLA 2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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