TY - JOUR
T1 - Second transplantation from HLA 2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation
AU - Tanaka, Takayuki
AU - Matsubara, Hiroshi
AU - Adachi, Souichi
AU - Chang, Hsi
AU - Fujino, Hisanori
AU - Higashi, Yuri
AU - Yasumi, Takahiro
AU - Kobayashi, Michihiro
AU - Watanabe, Ken Ichiro
AU - Takahashi, Munehisa
AU - Kobayashi, Yoshiro
AU - Maruya, Etsuko
AU - Saji, Hiroh
AU - Nakahata, Tatsutoshi
PY - 2004/12
Y1 - 2004/12
N2 - A 7-year-old girl with acute myelogenous leukemia with multilineage dysplasia received unrelated cord blood transplantation but developed hemophagocytic syndrome (HPS) after sepsis with methicillin-resistant coagulase-negative staphylococci before engraftment. Bone marrow aspiration on day 20 revealed a markedly increased number of activated macrophages showing hemophagocytosis. The presence of donor-type chimera in the bone marrow was confirmed at that time. We therefore quickly started immunosuppressive and antibacterial treatment. Although her condition gradually improved, the patient suffered graft failure due to HPS. She received peripheral blood stem cell transplantation from her HLA 2-loci-mismatched mother on day 54 and continued in complete remission 12 months after the second transplantation. The results in this case suggested that because of fetomaternal microchimerism it may be useful to select an HLA-haploidentical mother as a backup donor for stem cell transplantation.
AB - A 7-year-old girl with acute myelogenous leukemia with multilineage dysplasia received unrelated cord blood transplantation but developed hemophagocytic syndrome (HPS) after sepsis with methicillin-resistant coagulase-negative staphylococci before engraftment. Bone marrow aspiration on day 20 revealed a markedly increased number of activated macrophages showing hemophagocytosis. The presence of donor-type chimera in the bone marrow was confirmed at that time. We therefore quickly started immunosuppressive and antibacterial treatment. Although her condition gradually improved, the patient suffered graft failure due to HPS. She received peripheral blood stem cell transplantation from her HLA 2-loci-mismatched mother on day 54 and continued in complete remission 12 months after the second transplantation. The results in this case suggested that because of fetomaternal microchimerism it may be useful to select an HLA-haploidentical mother as a backup donor for stem cell transplantation.
KW - Fetomaternal
KW - Hemophagocytosis
KW - Second transplantation
KW - Sepsis
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U2 - 10.1532/IJH97.04063
DO - 10.1532/IJH97.04063
M3 - Article
C2 - 15646662
AN - SCOPUS:19944426985
SN - 0925-5710
VL - 80
SP - 467
EP - 469
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 5
ER -